What is the mechanism of action of this treatment?

Common treatments for Coronavirus, such as NAC, Alamax CR, and liposomal GSH, focus on reducing oxidative stress and enhancing cellular detoxification and immune function. NAC helps to liquefy mucus and combat oxidative stress, while glutathione (GSH) acts as a critical antioxidant protecting cells from damage and supporting immune function. Alpha lipoic acid (ALA) further contributes by regenerating other antioxidants like GSH. These mechanisms are vital for managing the inflammatory and oxidative damage seen in COVID-19 patients, potentially improving outcomes by reducing cellular damage and supporting overall immune health.

What side effects are associated with this type of intervention?

Jinhua Qinggan granules and Lianhua Qingwen have been studied for their effectiveness in treating COVID-19. Jinhua Qinggan granules have shown no obvious adverse reactions. Lianhua Qingwen has demonstrated improvements in symptoms such as fever, cough, fatigue, and muscle pain, with no significant difference in adverse reactions compared to conventional drugs. The combination of NAC, Alamax CR, and liposomal GSH, which are being studied for their antioxidant properties and enhancement of cellular detoxification and immune function, has not been associated with specific side effects in the provided context.

What prior FDA approvals exist?

The FDA has approved several treatments for COVID-19, including antiviral drugs like remdesivir and monoclonal antibodies such as bamlanivimab and casirivimab/imdevimab. These treatments primarily target the virus directly rather than focusing on antioxidant properties or cellular detoxification. While N-acetylcysteine (NAC) has been studied for its antioxidant effects and potential benefits in COVID-19, it has not received FDA approval specifically for this indication. Other investigational treatments, such as those combining NAC, Alamax CR, and liposomal glutathione (GSH), are still under clinical evaluation and have not yet been approved by the FDA.

What other types of research exist?

Promising novel alternatives for Coronavirus patients in 2024 include: 1) Sulforaphane, which has shown potential in enhancing cellular detoxification and immune function, particularly in autism spectrum disorder but may have broader applications. 2) Chinese medicinal herb-compound (CMHC), which has demonstrated protective efficacy against radiation damage and may offer similar benefits in enhancing immune function and cellular protection. 3) Lianhua Qingwen (LHQW) and Qingfei Paidu decoction (QFPD), traditional Chinese medicine formulas that target immunity and inflammation-related genes, potentially beneficial for COVID-19 treatment.

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Dietary Supplement

Antioxidant Supplements for Long COVID-19

Phase < 1

Waitlist Available

Research Sponsored by University of California, Irvine

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Patients with positive COVID testing (AB, RT PCR) and mild-severe symptoms based on COVID symptom list

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up will be evaluated at 2 weeks, 1-, 2-, 3- and 4 months post therapy

Awards & highlights

Summary

This trial is testing if a mix of supplements can help people with long-term COVID-19 symptoms. The supplements may reduce body damage and inflammation to improve these lingering symptoms.

Who is the study for?

This trial is for individuals who have tested positive for COVID-19 and are experiencing mild to severe long-haul symptoms. They must not have allergies or adverse reactions to NAC, ALA, or GSH, no meat product/gelatin allergies (alpha gal allergy), and no history of severe sulfa sensitivity.

What is being tested?

The study tests if glutathione combined with NAC and ALA can improve long COVID symptoms. Participants will be randomly assigned to receive these supplements with or without a multivitamin and magnesium, while their health status is monitored through questions and blood samples.

What are the potential side effects?

Potential side effects may include allergic reactions in those sensitive to the ingredients used: NAC, ALA, liposomal GSH. Side effects could range from mild digestive discomfort to more serious allergic responses.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I tested positive for COVID and have symptoms ranging from mild to severe.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ symptoms will be evaluated at 2 weeks, 1-, 2-, 3- and 4 months post therapy

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~symptoms will be evaluated at 2 weeks, 1-, 2-, 3- and 4 months post therapy

This trial's timeline: 3 weeks for screening, Varies for treatment, and symptoms will be evaluated at 2 weeks, 1-, 2-, 3- and 4 months post therapy for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Assess Changes in Symptoms of Post-Acute Sequelae of COVID (PASC)

COVID Severity of Symptoms Questionnaire

Change in Quality of Life Using SF-36 Survey

+1 more

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Arm AExperimental Treatment1 Intervention

Subjects randomized into Group A will take the following amount for 28 days * 4 capsules of NAC (600mg each) once in the morning and once in the evening * 1 tablet (600mg) of Alamax CR once in the morning and once in the evening * 8 capsules (250 mg each) of liposomal GSH in the morning and in the evening

Group II: Arm BActive Control1 Intervention

Subjects randomized into Group B will be taking a multivitamin and magnesium for 14 days. Afterwards, they will take the following for 14 days. * 4 capsules of NAC (600mg each) once in the morning and once in the evening * 1 tablet (600mg) of Alamax CR once in the morning and once in the evening * 8 capsules (250 mg each) of liposomal GSH in the morning and in the evening

0 / 1Eligibility criteria met

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

Common treatments for Coronavirus, such as NAC, Alamax CR, and liposomal GSH, focus on reducing oxidative stress and enhancing cellular detoxification and immune function. NAC helps to liquefy mucus and combat oxidative stress, while glutathione (GSH) acts as a critical antioxidant protecting cells from damage and supporting immune function. Alpha lipoic acid (ALA) further contributes by regenerating other antioxidants like GSH. These mechanisms are vital for managing the inflammatory and oxidative damage seen in COVID-19 patients, potentially improving outcomes by reducing cellular damage and supporting overall immune health.

Exploring the Pharmacological Mechanism of the Effective Chinese Medicines Against Gynecological Cancer Based on Meta-Analysis Combined With Network Pharmacology Analysis.Network pharmacology and computer-aided drug design to explored potential targets of Lianhua Qingwen and Qingfei Paidu decoction for COVID-19.Chemical composition and pharmacological mechanism of shenfu decoction in the treatment of novel coronavirus pneumonia (COVID-19).