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Tetracycline Antibiotic

Doxycycline for Rosacea

Phase < 1
Waitlist Available
Led By Raja Sivamani, MD, MS
Research Sponsored by University of California, Davis
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1-5 weeks
Awards & highlights

Summary

This trial studies how antibiotics change lipid molecules and the microbiome in people with rosacea. It aims to find new ways to treat rosacea by understanding these changes, potentially reducing the need for antibiotics.

Eligible Conditions
  • Rosacea
  • Ocular Rosacea

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1-5 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1-5 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Lipidome Change in Diversity
Lipidome Change in Quantity
Microbiome Change in Diversity
+1 more

Side effects data

From 2022 Phase 4 trial • 449 Patients • NCT04050540
3%
Malaria
100%
80%
60%
40%
20%
0%
Study treatment Arm
Standard of Care Arm
dPEP Intervention Arm

Trial Design

3Treatment groups
Experimental Treatment
Active Control
Group I: Ocular Rosacea SubjectsExperimental Treatment1 Intervention
Ocular rosacea subjects will receive mandatory Doxycycline intervention and will have samples collected at two visits, before starting intervention and at the completion of the intervention.
Group II: Cutaneous Rosacea SubjectsExperimental Treatment1 Intervention
Doxycycline intervention is optional for cutaneous rosacea subjects. If they do not participate, samples will only be collected at one visit after Dove soap washout. If they do decide to participate, samples will also be collected after completion of the Doxycycline intervention.
Group III: Healthy SubjectsActive Control1 Intervention
Healthy subjects will receive no intervention and will have samples collected only at one visit after Dove soap washout.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Doxycycline
2008
Completed Phase 4
~2650

Find a Location

Who is running the clinical trial?

University of California, DavisLead Sponsor
928 Previous Clinical Trials
4,720,988 Total Patients Enrolled
1 Trials studying Rosacea
265 Patients Enrolled for Rosacea
Raja Sivamani, MD, MSPrincipal InvestigatorUC Davis, Department of Dermatology
Mark Mannis, MDPrincipal InvestigatorUC Davis, Department of Ophthalmology
~4 spots leftby Sep 2025
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