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AMXT 1501 + DFMO for Cancer

Phase 1 & 2
Waitlist Available
Research Sponsored by Aminex Therapeutics, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patient is able to take oral medications and willing to use an at-home infusion pump
Active secondary malignancies will not be allowed
Must not have
Patients diagnosed with advanced solid tumors will not be eligible if they have a seizure disorder where >1 seizure has occurred within the last year
Patients with DIPG or DMG will not be eligible if they have seizure disorders that are not well-controlled
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights

Summary

This trial tests the safety of a pill called AMXT1501 combined with an IV drug in patients with advanced cancers. It aims to find out if this combination can safely help fight cancer by affecting cancer cells and blood cells. The IV drug has been studied with other drugs, showing potential in enhancing the effectiveness of chemotherapy in various animal cancer models.

Who is the study for?
This trial is for patients aged 12 and older, weighing over 40 kg, with various advanced solid tumors where standard treatments have failed or are not available. Participants must be able to take oral medication, use an at-home infusion pump, provide a CSF sample and tumor tissue biopsy, and agree to contraception use. Exclusions include recent cancer treatment within the last 4-6 weeks, uncontrolled seizures in DIPG/DMG patients, significant cardiovascular disease within the past 6 months, active liver disease or infections like HIV.
What is being tested?
The study tests AMXT 1501 dicaprate combined with IV DFMO on safety and optimal dosing levels in cancer patients. It's a Phase 1B/2A trial focusing on those with unresectable or metastatic solid tumors including ovarian cancer and gliomas among others.
What are the potential side effects?
While specific side effects are not listed here for AMXT1501 + DFMO combination therapy; generally such treatments may cause fatigue, nausea, digestive issues potentially due to oral intake of drugs; skin reactions from infusions; as well as risks associated with compromised bone marrow function.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I can take pills and am willing to use a pump for medicine at home.
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I do not have any other active cancers.
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I agree to use effective birth control during and for 3 months after the study.
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I have been diagnosed with DIPG or DMG and meet specific study requirements.
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I am 18 years old or older.
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My cancer cannot be surgically removed, has spread, and standard treatments have failed or are not available.
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I am 12 years or older and weigh more than 40 kg.
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I am fully active or restricted in physically strenuous activity but can do light work.
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I have been diagnosed with DIPG or DMG.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have not had more than one seizure in the past year.
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My seizures are well-controlled, and I have DIPG or DMG.
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I have an active liver condition.
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I have a GI condition or had surgery that may affect drug absorption.
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I am infected with HIV.
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I take biotin or supplements with more than 30 µg of biotin daily.
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I am not using any LHRH agonist/antagonist medications.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Determine DLTs and RP2Ds in AMXT 1501 in combination with IV DFMO
Determine safety and tolerability of AMXT1501 in combination with IV DFMO
Secondary study objectives
Characterize AMXT1501 and IV DFMO on the expression of immune related gene signatures
Characterize investigator defined Duration of Response (DOR)
Characterize investigator defined response Overall Response Rate (ORR) using RECIST v1.1
+2 more
Other study objectives
Palladium

Side effects data

From 2008 Phase 3 trial • 375 Patients • NCT00118365
17%
FATIGUE
16%
DIARRHEA
10%
HEADACHE
8%
NAUSEA
6%
TINNITUS
6%
COLD SYMPTOMS
6%
HEARING CHANGE
5%
WEIGHT LOSS
5%
SINUS CONGESTION
5%
UTI
5%
VOMITING
4%
FLU
4%
OTHER* HEARTBURN
4%
BLEEDING RECTAL
4%
WEIGHT LOSS INTENTIONAL
4%
EPIGASTRIC PAIN
4%
DIZZINESS
4%
ANOREXIA
3%
RESPIRATORY BRONCHITIS
3%
VERTIGO
3%
BLEEDING RECTAL HEMORRHOIDS
3%
HEARING
3%
HYPERTENSION
3%
PAIN* BACK
3%
URI
3%
CONSTIPATION
3%
COUGH*
2%
PAIN* BACK PAIN
2%
PAIN* LOW BACK
2%
LABS DECREASED WBC
2%
RASH
2%
HEARING LOSS
2%
LABS HEMATURIA
2%
LABS HYPERLIPIDEMIA
2%
ORAL* COLD SORES, LIPS
2%
BALANCE DISTURBANCE
2%
INFECTION* SINUS
2%
PAIN* RIGHT HEEL
2%
INDIGESTION
2%
LABS DECREASE IN HGB
2%
BALANCE
2%
ABDOMINAL PAIN
2%
OTHER* INSOMNIA
2%
CORONARY ARTERY DISEASE
2%
BLOOD IN STOOL
2%
HEARING HEARING CHANGE
1%
FX (L) ELBOW
1%
QUADRUPLE BYPASS SURGERY FOR CAD, UNSTABLE ANGINA
1%
DERMATOLOGY* BASAL CELL CARCINOMA
1%
ERECTILE DYSFUNTION
1%
FATIGUE* WEAKNESS
1%
FLU FLU-LIKE SYMPTOMS
1%
FORHEAD LESION REMOVAL
1%
MUSCULOSKELETAL CRAMPS THIGHS BILATERAL
1%
NECK PAIN
1%
OTHER* PRURITIUS, HIPS AND BELLY
1%
FINGER LACERATION RIGHT HAND
1%
GI ABDOMINAL BLOATING
1%
HEARING AUDIOGRAM ONLY
1%
HEMATARIA
1%
BROKEN TOE
1%
LABS HGB DECREASE GREATER THAN 10%
1%
OTHER* HEARTBURN X5 EPISODES
1%
SERUM GLUCOSE
1%
OTHER* PRURITUS, INTERMITTENT, BELLY, HIPS, LEGS
1%
RESPIRATORY BRONCHIAL ASTHMA
1%
FLU SYMPTOMS
1%
HEARING LOSS IN LEFT EAR
1%
HEARING OTOTOXICITY - AUDIOGRAM ONLY
1%
OTHER* ARTHRALGIA LOWER BACK
1%
HEARING AUDITORY
1%
OTHER* DRY EYES
1%
OTHER* INCREASED DEPRESSION
1%
MUSCULOSKELETAL TAILBONE INJURY
1%
RASH RIGHT CHEEK
1%
STOOL* LOOSER
1%
GI UPSET STOMACH X 2 EPISODES
1%
LABS ELEVATED PSA
1%
MUSCULOSKELETAL BILATERAL THIGH CRAMPS
1%
OTHER* ALLERGY SYMPTOMS
1%
OTHER* ARTHRALGIA NECK
1%
OTHER* HEARTBURN X 3 EPISODES
1%
OTOTOXICITY* R/EAR CLOGGED
1%
PERIPHERAL NERVOUS SYSTEM* PARESTHESIA BILAT TINGLING IN SHOULDERS
1%
PERIPHERAL NERVOUS SYSTEM* RIGHT FOOT TOE NUMBNESS
1%
RASH ABDOMINAL
1%
STOOL* LOOSE, 2-3 DAYS/WEEK
1%
TINNITUS PRE-EXISTING - INCREASED
1%
RESPIRATORY CHEST COLD SX, DX WITH PNEUMONIA RIGHT LUNG
1%
ARTHRITIS OSTEO
1%
CHANGE IN SIGNIFICANT OTHER'S PERCEPTION OF HEARING
1%
CRAMPING
1%
FATIGUE* SYNCOPE
1%
FEVER X 2DAYS
1%
GI BARRETT'S ESOPHAGUS
1%
GI UPSET STOMACH X3 EPISODES
1%
MUSCULOSKELETAL MIDDLE FINGER CYST
1%
MUSCULOSKELETAL MUSCLE PAIN, RIGHT LEG
1%
OTHER* ALLERGIC RHINITIS
1%
OTHER* PROSTATIC ADENOCARCINOMA DX 7/01/03 BY BX
1%
OTHER* TINGLING LEFT FOOT
1%
RESPIRATORY RHINITIS
1%
OTHER* INFECTION SINUS
1%
OTHER* LACERATION, ER VISIT
1%
OTHER* ORAL SORENESS; ABCESS LOWER GUM
1%
DERMATOLOGY* SKIN - BUMP, RED LEFT UPPER MOUTH
1%
HYPERTENSION /DIABETES
1%
OTHER* PAIN-LEFT ANKLE
1%
HAND SURGERY - TRIGGER FINGER
1%
INCREASE FREQ OF HEMORHOIDAL BLEEDING
1%
OTHER* BAD COLD X 3 WKS
1%
OTHER* PHLEBITIS LEFT FOREARM
1%
OTHER* PRURITUS, INTERMITTENT, HIPS
1%
OTHER* STIFF FINGERS RIGHT. GOLF?
1%
HEARING AUDIOGRAM GRADE 1 HEARING CHANGE
1%
HEARING CHANGE AUDIOGRAM
1%
OTOTOXICITY* LEFT EAR
1%
INFECTION* PNEUMONIA POSS "SCAR" ON CXR
1%
MUSCULOSKELETAL CRAMPS THIGH RIGHT
1%
MUSCULOSKELETAL SHOULDER PAIN CONTINUES
1%
OTHER* PRURITIUS LEGS
1%
OTHER* TENDON, BRUISED RIGHT ELBOW
1%
PAIN* LEFT FOOT
1%
RESPIRATORY ASTHMA FLARE-UP, WHEEZING, SOB
1%
RESPIRATORY CHEST CRX, PNEUMONIA RIGHT LUNG
1%
RESPIRATORY SHORTNESS OF BREATH 2X
1%
SWOLLEN ANKLES (PERIPHERAL EDEMA)
1%
TINNITUS INCREASED, LEFT EAR
1%
UTI WITH SEPSIS
1%
INFECTION* EUSTACHIAN TUBES
1%
MENTAL AND PHYSICAL BREAKDOWN
1%
LABS LOW HEMOGLOBIN AFTER SURGERY
1%
NECK PAIN, INJURY
1%
OTHER* BACK PAIN AND DIARRHEA
1%
STOMACH FLU
1%
ORAL* LESION
1%
DERMATOLOGY* DRY SKIN, FEET
1%
ORAL* ULCERS
1%
OTHER CONJUNCTIVITIS, WITH OP EYE SURGERY
1%
OTHER* + + PITTING BILATERAL ANKLE EDEMA
1%
OTHER* BASAL CELL CARCINOMA LEFT CLAVICLE
1%
OTHER* FOOD POISONING: DIARRHEA. VOMITTING
1%
CENTRAL NERVOUS SYSTEM HEADACHE RELATED TO CHOCOLATE
1%
CONSTIPATION GETTING WORSE
1%
DIARRHEA MILD
1%
DIARRHEA OCCASIONAL
1%
ENLARGED THYROID
1%
FLU ACHY, NAUSEA, HEADACHE, COUGH
1%
FLU DIARRHEA N/V
1%
FOOT CONTUSION
1%
GENITOURINARY URINATING
1%
GI HEARTBURN
1%
GI INFLAMMATION COLITIS
1%
H. PYLORI +, STOMACH UPSET
1%
HEARING HEARNING LOSS/ SUBCLINICAL
1%
INDIGESTION HEART BURN
1%
INFECTION* FUNGAL INFECTION FINGERNAILS
1%
INFECTION* LEFT INDEX FINGER
1%
LABS HGB DECREASE = 10%
1%
PERIPHERAL NERVOUS SYSTEM* ARMS TINGLE/GO NUMB
1%
PERIPHERAL NERVOUS SYSTEM* MILD PARESTHESIA BOTH HANDS
1%
RESPIRATORY SHORTNESS OF BREATH
1%
RESPIRATORY SINUSITIS
1%
SHINGLES
1%
SINUSITIS
1%
WEAKNESS
1%
WEIGHT LOSS >5%
1%
WEIGHT LOSS DIETING
1%
GI BLOATING / GAS
1%
GI CECUM BIOPSY: EROSIM WITH CHRONIC INFLAMMATION, NON-SPECIFIC
1%
H.PYLORI +, DX IBS - CONSTIPATION
1%
HAND PAIN
1%
LUMBAR HERNIATED DISC AND LUMBAR RADICULOPATHY
1%
BROKEN TOOTH
1%
HEAD CONGESTION
1%
HEARTBURN
1%
INCREASE FLATULENCE
1%
INFECTION* FUNGAL, LEFT MIDDLE FINGER
1%
INFECTION* MIDDLE EAR-BLOCKED EUSTACHIAN TUBE
1%
KNEE PAIN
1%
LABS 10% DROP HGB
1%
LABS ANEMIA: IRON DEFICIENCY
1%
LABS DECREASED HEMOGLOBIN, REDRAW 12/4/01
1%
ORAL* PRE-ABSCESS
1%
OTHER* PROSTATE CANCER
1%
OTHER* THROAT IRRITATION
1%
RESPIRATORY SHORT OF BREATH
1%
SINUS CONGESTION SINUSITIS
1%
RIGHT HIP PAIN
1%
BLEEDING IN EYE FROM THORN
1%
BRUISING LEFT HIP AREA
1%
CENTRAL NERVOUS SYSTEM MEMORY PROBLEMS
1%
FEELING HEATED AFTER TAKING MEDICATION
1%
FEVER
1%
FEVER X1
1%
FLU X5 DAYS
1%
GENITOURINARY - URINATING
1%
GOUT
1%
HEARING AUDIOMETRIC CHANGE RIGHT EAR/ OVERALL NO SIGNIFICANT CHANGE
1%
HEARING HEARING LOSS
1%
HEARING HEARING LOSS AUDIOMETRY ONLY
1%
HEARING INNER EAR
1%
HYPERKALEMIA
1%
INFECTION* FUNGAL FINGERNAIL
1%
INFECTION* INSECT BITE RIGHT ANKLE
1%
INFECTION* LEFT LOWER LEG AK SITE
1%
LABS DROP IN HGB AND HEMATOCRIT
1%
LABS ELEVATED BILIRUBIN
1%
LABS ENDOCRINE: ELEVATED BLOOD GLUCOSE
1%
LEFT FLANK PAIN
1%
MUSCULOSKELETAL BACK PAIN
1%
MUSCULOSKELETAL SHOULDER PAIN
1%
MUSCULOSKELETAL SPRAINED ANKLE
1%
OTHER* ALLERGIES
1%
OTHER* ARTHRALGIA LEFT ELBOW
1%
OTHER* ARTHRALGIA LEFT WRIST
1%
OTHER* CYST IN GROIN WITH INFECTION
1%
OTHER* DISCOMFORT POST PROSTATE BIOPSY
1%
OTHER* IMPOTENCE
1%
OTHER* PHLEBITIS SUPERFICIAL LEFT FOREARM
1%
OTHER* PLANTAR FASCIITIS
1%
OTHER* RECTAL MOISTNESS
1%
PAIN
1%
PAIN* LOWER BACK STIFFNESS
1%
PAIN* RIGHT SHOULDER PAIN
1%
PERIPHERAL NERVOUS SYSTEM* MILD PARESTHESIA
1%
ROSACASE
1%
SINUS INFECTION
1%
SPRAINED ANKLE
1%
STOOL* HIGHER FREQUENCY
1%
STOOL* LOOSE
1%
TINGLING IN FINGER TIPS (NEUROPATHYSENSORY)
1%
VISION CATARACT
1%
VISION CATARACTS, "FLASHING LIGHT"
1%
VISION FLOATERS, RIGHT EYE
1%
ARTHRITIS R THUMB JOINT PAIN R/T
1%
BLOOD IN STOOL OCCULT
1%
CHANGE
1%
ERYTHORMATOUS PLAQUES
1%
HEARING AUDIOMETRIC CHANGE BILATERAL
1%
HEMATURIA-MICROSCOPIC
1%
HEMMORRHOID
1%
HEMORRHOIDS
1%
HIGH BLOOD PRESSURE
1%
HIP AREA
1%
HTN
1%
HYPERGLYCEMIA
1%
INCREASED CREATININE
1%
MUSCULOSKELETAL MINOR BACK PAIN
1%
NAUSEA RELATED TO NEW MEDICINE GLUCOPHAGE
1%
NECK AND SHOULDER PAIN
1%
NEUROLOGY - DIZZINESS
1%
OTHER* DEPRESSION
1%
OTHER* DEPRESSION - RECURRANCE
1%
OTHER* INCREASE IN DEPRESSION
1%
OTHER* OCULAR/VISUAL MYOPIA
1%
PAIN* TESTICULAR SORENESS & SWELLING
1%
PAIN* TOOTH
1%
PAIN* UPPER RIGHT QUADRANT
1%
RESPIRATORY SOB 6 EPISODES
1%
RESPIRATORY UPPER, INFLUENZA
1%
RIGHT SIDE ABOVE EAR
1%
SEASONAL ALLERGIES
1%
STOOL* SOFT WITH ABDOMINAL CRAMPS
1%
STOOL* TARRY
1%
SUBCONJUNCTIVAL HEMORRHAGE
1%
SURGERY* CABG WOUNDS (CORONARY ARTERY BYPASS GRAFT)
1%
SURGERY* HERNIA
1%
TINNITUS X1 EPISODE
1%
VERTIGO POSITIONAL
1%
VISION BLURRED
1%
WEIGHT LOSS DURING RUN-IN PERIOD
1%
ARTHRITIS IN RIGHT KNEE
1%
ARTHRITIS LEFT HAND JOINT PAIN R/T ARTHRITIS
1%
ANOREXIA DECREASED APPETITE
1%
ANXIETY AND DEPRESSION
1%
ABDOMINAL PAIN DIARRHEA X 3-4 DAILY, CRAMPING
1%
ABNORMAL PSA
1%
ARTHRITIS LEFT WRIST
1%
ANXIETY MOOD SWINGS, HOT FLASHES, ANXIETY
1%
ARTHIALGIA SHOULDER
1%
ARTHRITIS ARTHRITIS FLARE UP - HANDS
1%
ARTHRITIS BACK PAIN WORSENING
1%
ARTHRITIS BILATERAL KNEE PAIN R/T
1%
CHEST PAIN X 3 WKS, R/O CORONARY ARTERY DISEASE
1%
HOSPITALIZATION FOR PANCREATIC NEOPLASM
1%
HOSPITALIZATION; APPENDICITIS
1%
CELLULITIS
1%
ARTHRITIS THUMB PAIN - ARTHRITIS BOTH HANDS
1%
ARTHRITIS TOE PAIN
1%
ASTHMA FLARE-UP
1%
BACK PAIN, ON MOTRIN
1%
BALANCE BALANCE DISTURBANCE
1%
BELLS PALSY SIDE WEAKNESS
1%
BACK STRAIN
1%
BASAL CELL SKIN LESION REMOVAL
1%
BIL SWOLLEN FEET AND ANKLES
1%
BLEEDING* HEMORRHAGE HEMATURIA
1%
BLEEDING* PROLONGED MENSTRUAL BLEEDING
1%
BLEEDING* VAGINAL BLEED
1%
BLEEDING, RECTAL
1%
BLOOD IN STOOL /HEMORRHOID
1%
CARDIAC* DX -- POSSIBLE RETURN OF RENOVASCULAR HTN
1%
CARDIAC* HEART ATTACK
1%
CARDIAC* TACHYCARDIA
1%
CARDIAC* TACHYCARDIA EPISODES - INCREASED FREQUENCY
1%
CARDIAC* UNSTABLE ANGINA, CHEST PAIN
1%
COLD SYMPTOMS COUGH AND COLD SYMPTOMS
1%
COLD SYMPTOMS NASAL CONGESTION
1%
COLD SYMPTOMS WITH COUGH
1%
COLD WITH URI SX
1%
COLD/SINUS/EAR CONGESTION
1%
DECREASED PERIPHERAL REFLEXES
1%
DERMATOLOGY* 2 SPOTS ON SCALP
1%
DERMATOLOGY* ACTINIC KERATOSES REMOVED X3
1%
DIARRHEA X 1 RELATED TO FOOD
1%
DYSPNEA ON EXERTION
1%
EPIGASTRIC PAIN GERD
1%
CONGESTIVE HEART FAILURE
1%
BASAL CELL CARCINOMA
1%
ANEURYSM
1%
CHEST PAIN AND PALPITATIONS
1%
INFARCT MYOCARDIAL
1%
LEFT URETERAL STONES, OBSTRUCTING
1%
PNEUMONIA; POSSIBLE COPD EXACERBATION
1%
ABDOMINAL PAIN MOST LIKELY SECONDARY TO ACUTE CHOLECYSTITIS
1%
ACUTE MYOCARDIAL INFARCTION
1%
GASTROINTESTINAL BLEEDING
1%
ARRYTHMIA SINUS
1%
HOSPITALIZATION - OVERNIGHT OBSERVATION; LEFT KIDNEY BIOPSY
1%
KIDNEY CALCULUS
1%
MYOCARDIAL INFARCTION/CHEST PAIN, ABNORMAL CARDIAC ENZYMES
1%
BIPOLAR, EXACERBATED
1%
CELLULITIS OF RIGHT LEG
1%
OBSTRUCCTIVE JAUNDICE
1%
ACUTE SHORTNESS OF BREATH; CAD; UNSTABLE ANGINA
1%
AORTIC STENOSIS
1%
HOSPITALIZATION UTI
1%
HOSPITALIZATION VAGINAL BLEEDING TOTAL HYSTERECTOMY
1%
HOSPITALIZATION; FRACTURE OF LEFT ANKLE REQUIRING SURGICAL INTERVENTION
1%
LEFT LEG CELLULITIS
1%
PARATHYROID DISORDER
1%
PROLAPSED CYSTOCELE; TOTAL HYSTERECTOMY WITH BILATERAL SALPINGO-OOPHORECTOMY
1%
RIGHT KNEE PAIN
1%
STERNAL WOUND SURGICAL DEBRIDEMENT
1%
ABDOMINAL PAIN ABD. CRAMP AND CONSTIPATION
1%
ABDOMINAL PAIN ABDOMINAL CRAMPING
1%
GI INCREASE IN GERD SYMPTOMS
1%
HEADACHE WITH VISION INVOLVEMENT
1%
HEARING /INNER EAR - "STATIC NOISE" LEFT
1%
HEARING AUDIO CHANGE SUBCLINICAL
1%
HEARING AUDIOGRAM
1%
HEARING CHANGE NOTED ON AUDIO
1%
HEARING CHANGE PER AUDIOGRAM
1%
HEARING DECREASE IN HEARING ABILITY
1%
HEARING DECREASED
1%
HEARING DIFFICULTY
1%
HEARING SELF PERCEPTION
1%
HEARING SELF PERCEPTION, DIFFICULTY WITH DISCRIMINATION
1%
INCREASE STOOL FREQUENCY
1%
INCREASE STOOLING
1%
INCREASED ALKPHOSPHATASE
1%
INCREASED AST
1%
INCREASED BILIRUBIN
1%
INFECTION* RIGHT MIDDLE FINGER NAIL
1%
INFECTION* YEAST
1%
INFECTION* SINUS INFECTION
1%
INFECTION* TOOTH
1%
LABS B-12 DEFICIENCY
1%
LABS DECREASE HGB GREATER THAN 10%
1%
LABS DECREASED HBG OF 10% BASELINE
1%
LABS LOW HGB = 10%
1%
MUSCULOSKELETAL GANGLION CYST
1%
MUSCULOSKELETAL INCREASED BACK PAIN
1%
NOSEBLEED
1%
NUMBNESS/TINGLING OF RIGHT ARM
1%
ORAL* BLISTER ROOF OF MOUTH
1%
ORAL* CANKER SORES ON TONGUE
1%
ORAL* CHAPPED LIPS
1%
OTHER* 2 LUMPS IN GROIN AREA (SIZE 2 X 2 CM)
1%
OTHER* BIOPSY OF SKIN NEOPLASM, ABD. CYST AND THIGH
1%
OTHER* BLADDER POLYP
1%
OTHER* DX OF DIABETES
1%
OTHER* ENDOCRINE -- HOT FLASHES
1%
OTHER* GENITOURINARY "TWINGE" RIGHT TESTICLE
1%
OTHER* GENITOURINARY, LEFT TESTICLE TENDER/SWOLLEN
1%
OTHER* MILD PARESTHESIA
1%
OTHER* NASAL DISCHARGE
1%
OTHER* PARESTHESIA-LEFT ARM
1%
OTHER* PERIANAL ABSCESS
1%
OTHER* PERIANAL SWELLING
1%
OTHER* SCRATCHY THROAT/SNIFFLES
1%
OTHER* SLEEP APNEA
1%
OTHER* SNIFFLES
1%
OTHER* SOB CHEST TIGHTNESS, POSSIBLE GERD SX
1%
PAIN* IN FRONT OF LEFT UPPER THIGH
1%
PAIN* KNEE
1%
PAIN* RIGHT HEEL - PLANTAR FASCIITIS
1%
PAIN* RIGHT HIP AND KNEE
1%
PAIN* RIGHT KNEE - INCREASE
1%
PERIPHERAL NERVOUS SYSTEM* NEURO SCIATIC RIGHT LEG
1%
PERIPHERAL NERVOUS SYSTEM* NEURO SCIATICA RIGHT LEG
1%
PERIPHERAL NERVOUS SYSTEM* OLD INJURY
1%
PERIPHERAL NERVOUS SYSTEM* PARESTHESIA
1%
RESPIRATORY COUGH
1%
RESPIRATORY DYSPNEA ON EXERTION
1%
RESPIRATORY INFECTION, BRONCHITIS
1%
RESPIRATORY PNEUMONIA
1%
SORE THROAT, MUCUS/COUGH
1%
SPINNING
1%
SURGERY* PROSTATE RESTRUCTURING-ELECTIVE
1%
SURGERY* RIGHT INGUINAL HERNIA REPAIR
1%
SURGERY* TURP/HOSPITAL
1%
SWELLING PERIPHERAL EDEMA
1%
TOOTH INFECTION -> ROOT CANAL
1%
VISION SUB-CONJUNCTIVAL HEMMORHAGE
1%
VOMITING NAUSEA AND VOMITING
1%
PAIN* RIGHT SIDED PAIN AFTER EXERCISE
1%
BIL LE EDEMA
1%
FEVER INTERMITTENT
1%
MUSCULOSKELETAL ANKLE INJURY, LEFT, R/T MISSTEP
1%
ORAL* PAIN - SOFT PALATE POST SURGICAL
1%
ORAL* SORENESS
1%
ORAL* YEAST INFECTION
1%
OTHER* BACK STRAIN
1%
OTHER* BLOATING
1%
OTHER* BLOATING, HX IBS
1%
OTHER* DECREASED THYROID FUNCTION, THIN HAIR, DECREASED TEMP, DRY SKIN
1%
OTHER* DEGENERATIVE JOINT DISEASE-RIGHT GREAT TOE
1%
OTHER* HSV OUTBREAK
1%
OTHER* HT OF GASTRIC ULCERS
1%
OTHER* HTN
1%
PAIN* EAR PAIN
1%
PAIN* LEFT HIP
1%
PAIN* MILD BACK PAIN "BURNING"
1%
PAIN* RIGHT SHOULDER
1%
RESPIRATORY SOB WITH EXERTION
1%
RESPIRATORY UPPER, SINUS PROBLEM ALLERGY RELATED
1%
STOMACH UPSET AND HEARTBURN
1%
TINNITUS MAY HAVE INCREASED
1%
CARDIAC* HEART MURMUR
1%
GASTRITIS
1%
OTHER* GENERAL ACHES
1%
LABS HGB DROP 10%
1%
COLD SYMPTOMS SINUS DRAINAGE
1%
DYSPNEA
1%
DYSPNEA (SHORTNESS OF BREATH)
1%
GI UPPER GI PAIN/ACID REFLUX
1%
HEARING DECREASE IN HEARING
1%
HERPES
1%
HIP BURSITIS
1%
INCREASED FLATULENCE; ANAL INCONTINENCE
1%
INCREASED FREQUENCY OF DROPPING ITEMS
1%
INFECTION* BLADDER INFECTION
1%
INFECTION* ESOPHAGITIS
1%
INFECTION* VAGINAL YEAST
1%
MUSCULOSKELETAL BUMP INTERIOR TO LEFT ELBOW
1%
MUSCULOSKELETAL OLECRANON BURSITIS/CELLULITIS/ELBOW SWELLING
1%
OTHER* BURSITIS - SHOULDER
1%
OTHER* LOOSE STOOL
1%
OTHER* LOWER EXTREMITY EDEMA
1%
OTHER* MODERATE PARESTHESIA
1%
OTHER* MODERATE PARESTHESIA IN RIGHT HAND
1%
OTHER* NAIL AVULSION, LEFT HALLUX NAIL
1%
OTHER* ULCERATION, RT LOWER EXTREMITY
1%
PAIN* FINGER PAIN
1%
PAIN* FROM SEED IMPLANT FOR PROSTATE CA
1%
PAIN* GAS
1%
PERIPHERAL NERVOUS SYSTEM* PARESTHESIA L/HAND NUMBNESS
1%
TOOTH ABCESS
1%
CENTRAL NERVOUS SYSTEM MEMORY LOSS INCREASED
1%
HIP PAIN
1%
REMOVAL PRE-CAN SK.
1%
ANXIETY DEPRESSION
1%
HEART DISEASE: A. CORONARY, B. NON-Q-WAVE INFARCTION, C. UNSTABLE ANGINA; CORONARY STENTING
1%
PROBABLE RIGHT SUBCORTICAL INFARCT
1%
CENTRAL NERVOUS SYSTEM
1%
CHEST PAIN RELATED TO 4/18 REPORT FOR HEART BURN
1%
DERMATOLOGY* BCC
1%
DERMATOLOGY* FACIAL EDEMA
1%
DERMATOLOGY* ROSACEA
1%
DIZZINESS/VERTIGO EPISODE LASTING LESS THAN 10 SEC
1%
GI HEARTBURN X9 EPISODES
1%
HEARING SLIGHT LOSS
1%
HYPERGLICEMIA
1%
HYPERTENSION RETURNED
1%
HYPERTENSION SUSPECT OCULAR HYPERTENSION
1%
INCREASE "BURPING"
1%
INCREASED ALT
1%
INFECTION* INFECTED SCROTAL CYST
1%
PAIN* LEFT ANKLE
1%
KIDNEY PROBLEMS
1%
KIDNEY PROBLEMS/RENAL-OTHER
1%
KIDNEY STONES
1%
LABS ANEMIA
1%
LABS DECREASED HBG 10% FROM BASELINE
1%
LABS DECREASED HEMOGLOBIN NOT GREATER THAN 10% BASELINE
1%
LABS DECREASED HGB
1%
LABS DECREASED HGB GREATER THAN 10% BASELINE
1%
LABS DECREASED HGB, 10% FROM BASELINE
1%
LABS DECREASED HGB: CHRONIC
1%
LABS INCREASED CHOLESTEROL
1%
LABS PROTEINURIA
1%
LEG PAIN
1%
LOOSE STOOL
1%
LYMPHADENITIS RIGT NECK
1%
MUSCULOSKELETAL BACK SPASM
1%
MUSCULOSKELETAL FOOT PAIN
1%
MUSCULOSKELETAL L2, L3 DISKS
1%
MUSCULOSKELETAL MUSCLE SORENESS - R FOREMARM
1%
MUSCULOSKELETAL MUSCLE WEAKNESS/SORENESS
1%
MUSCULOSKELETAL RIGHT KNEE TORN MENISCUS
1%
PAIN* LEFT HEEL BONE SPUR
1%
MUSCULOSKELETAL TORN ROTATOR CUFF, LEFT
1%
NAUSEA 5 EPISODES
1%
NAUSEA NAUSEA/DIARRHEA/HEADACHE
1%
NEUROPATHY/SENSORY; TINGLING IN FINGERS
1%
ORAL* DRY MOUTH
1%
ORAL* EXACERBATION/ LICHEN PLANUS
1%
ORAL* MOUTH SORE
1%
ORAL* MOUTH SORES
1%
ORAL* PAIN IN MOUTH POST PERIODONTAL SURGERY
1%
ORAL* PAIN RIGHT UPPER MOLAR
1%
OTHER* ANAL FISTULA
1%
OTHER* ANAL FISTULA, SURG REPAIR
1%
OTHER* ARTHRALGIA LEFT ANKLE
1%
OTHER* BASAL CELL CARCINOMA LEFT JAW
1%
OTHER* BODY ACHES
1%
PAIN* MUSCLE STRAIN/SPASM
1%
PAIN* NECK
1%
PAIN* NECK & BACK
1%
OTHER* BRACHY THERAPY FOR PROSTATE CA
1%
OTHER* CELLULITIS RIGHT KNEE
1%
OTHER* CHEST X-RAY ABNORMAL, RIGHT UPPER LOBE LESION
1%
OTHER* CLAUDICATION
1%
OTHER* COLD SORE (NOSE)
1%
OTHER* CRAMPING
1%
OTHER* CYST ON BACK, DRAINED 10/10/00
1%
OTHER* DECREASED LIBIDO
1%
OTHER* DIABETES
1%
OTHER* DIFFICULTY SWALLOWING(DYSPHAGIA)
1%
OTHER* DYSPHAGIA
1%
OTHER* DYSPLASIA PROSTATE
1%
OTHER* EAR PAIN AND PRESSURE
1%
OTHER* ENLARGED PROSTATE, PT PLACED ON PROZOSIN
1%
OTHER* ESOPHAGEAL SPASM
1%
OTHER* F/U 6MO CT
1%
OTHER* FEELS "FUZZY" IN HER HEAD
1%
OTHER* GENITOURINARY/ VAGINITIS
1%
OTHER* GERD
1%
OTHER* GLAUCOMA
1%
OTHER* GLAUCOMA INCREASED
1%
PAIN* LEFT KNEE
1%
OTHER* HEMOPTISIS
1%
OTHER* HOT AND SWEATY
1%
OTHER* INSOMNIA INCREASE
1%
OTHER* LEFT BREAST NODULE
1%
OTHER* LESION ON RIGHT THIGH
1%
OTHER* LUMP IN RIGHT GROIN, LYMPHADENOPATHY
1%
OTHER* OCCASIONAL BRUISING
1%
OTHER* OCULAR - INCREASE INTRAOCULAR PRESSURE LEFT EYE
1%
OTHER* PLANTAR FASCIITIS LEFT FOOT
1%
OTHER* REDDENED EYES
1%
OTHER* RETINA EDEMA, POST OP
1%
OTHER* RIGHT EAR PRESSURE
1%
PAIN* LEFT SHOULDER
1%
PAIN* MUSCLE STRAIN (PAIN) IN LOWER BACK (OCCASIONAL)
1%
OTHER* SHADOW IN LEFT LUNG, POSS. BENIGN TUMOR OR SCAR TISSUE. CT 3/10/04
1%
OTHER* SORE THROAT
1%
OTHER* SPIDER BITE (LEG) SWELLING
1%
OTHER* TURP
1%
OTHER* VAGINAL ITCHING
1%
OTHER* WHITE BLOOD CELL COUNT INCREASE
1%
PAIN AND LOCAL SWELLING, UPPER LEFT MOLAR
1%
PAIN IN LOWER CALF
1%
PAIN* "VAGUE PAIN" WEAKNESS LEFT LEG
1%
PAIN* ALL OVER BODY
1%
PAIN* BACK INTERMITTENT
1%
PAIN* BACK PAIN WHILE EXERCISING
1%
PAIN* BACK X2 EPISODES
1%
PAIN* BILATERAL KNEE SORENESS
1%
PAIN* BREAST TENDERNESS
1%
PAIN* CHEST
1%
PAIN* CHEST; EXACERBATION OF PREVIOUS CONDITION
1%
PAIN* EAR ACHE
1%
PAIN* FLANK PAIN, KIDNEY STONES
1%
PAIN* FOOT PAIN/SORE
1%
PAIN* HIPS/BACK
1%
PAIN* PAIN IN LEFT LEG AND KNEE
1%
PAIN* POST - SURGICAL
1%
PAIN* POST TOOTH EXTRACTION
1%
PAIN* PULLED MUSCLE
1%
PAIN* RIGHT BUTTOCKS
1%
PAIN* RIGHT FLANK
1%
PAIN* RIGHT KNEE
1%
PAIN* RIGHT LEG PAIN
1%
PAIN* RIGHT SHOULDER BLADE
1%
PAIN* SCORPION BITE RIGHT FOREARM
1%
PAIN* SHIN LACERATION
1%
PAIN* SHOULDERS
1%
PAIN* SORE KNEE
1%
PAIN* SORE ON THUMB
1%
PAIN* SORE THROAT
1%
PAIN* STIFF NECK R/T HEAD BUMP IN BATH
1%
PAIN* TAILBONE
1%
PERIPHERAL NERVOUS SYSTEM*
1%
PERIPHERAL NERVOUS SYSTEM* SPINAL STENOSIS
1%
POSSIBLE RENAL CALCULUS (TOOK 1 VICODINE)
1%
PROTRUDING AND TENDER HEMORRHOIDS
1%
RASH BODY AND EXTREMITIES
1%
RASH RIGHT FOOTECZEMA
1%
RASH RIGHT FOREARM
1%
RASH RIGHT LEG
1%
REFLUX GERD
1%
REFLUX GERD EPISODE
1%
REFLUX GERD EPISODIC
1%
REFLUX INCREASED GERD, NUMBER OF EPISODES
1%
RELEASE OF CARPAL TUNNEL IN RIGHT HAND
1%
RESPIRATORY ALLERGIES/ASTHMA
1%
RESPIRATORY ASTHMA FLARE UP
1%
RESPIRATORY CHRONIC RHINITIS CONTINUES
1%
RESPIRATORY COLD
1%
RESPIRATORY DX WITH BRONCHIAL PNEUMONIA
1%
RT ELBOW FX
1%
SINUS CONGESTION ALLERGIES
1%
SLEEP APNEA
1%
SLIGHT QUEEZY STOMACH
1%
SQUAMOUS CELL REMOVAL
1%
STOMACH PAIN
1%
STOMACH VIRUS (VIRAL GASTROECTERITIS)
1%
UPPER HARD PALATE 1 CM ERYTHEMA W/ ULCER
1%
UPPER RESPIRATORY INFECTION
1%
VISION DISTURBANCE
1%
VISION GLAUCOMA
1%
WOUND INFECT
1%
ABDOMINAL PAIN CRAMPING
1%
GASTRIC REFLUX
1%
LOWBACK PAIN
1%
MUSCULOSKELETAL THIGH CRAMPS BILATERAL
1%
NAUSEA AND BELCHING
1%
NAUSEA POST SURGICAL
1%
ORAL* GUM PAIN
1%
ORAL* INCREASED SALIVA
1%
CARDIAC* CONGESTIVE HEART FAILURE
1%
CARDIAC* FLUID IN LUNGS
1%
CHOLECYSTITIS
1%
ACUTE SHORTNESS OF BREATH R/T CHF, IMPROVED
1%
BROKEN RIGHT TIBIA UNDER KNEE D/T MVA
1%
CARCINOMA PROSTATIC
1%
CHEST PAIN
1%
CEREBRAL INFARCTION
1%
GI BLEED R/T DIVERTICULA
1%
MVA
1%
CHANGE IN HEARING PER AUDIOGRAM
1%
CHEST PAIN WITH EXERTION
1%
PANCREATITIS
1%
COLD
1%
PNEUMONIA
1%
COLD SYMPTOMS COLD X3-4
1%
COLD SYMPTOMS HEAD
1%
COLD SYMPTOMS DX SINUS INFECTION
1%
ABDOMINAL PAIN ABD CRAMPING AND BLOAT
1%
ABDOMINAL PAIN DIARRHEA X 1-2 DAILY, CRAMPING
1%
ABDOMINAL PAIN CRAMPS/ CONSTIPATION
1%
COLD SYMPTOMS SNIFFLES
1%
ABDOMINAL PAIN EPIGASTRIC PAIN
1%
ABDOMINAL PAIN LEFT SIDE
1%
ABDOMINAL PAIN OCCASIONAL ABD CRAMP WITH LOOSE STOOL WHEN NERVIOUS
1%
ARTHRITIS
1%
ABDOMINAL PAIN STOMACH CRAMPS
1%
ABNORMAL X-RAY
1%
ANOREXIA LOSS OF APPETITE
1%
ANXIETY
1%
GLUCOSURIA
1%
ASTHMA
1%
GI STOMACH CRAMPS
1%
BLACK STOOLS (THINKS FROM MAALOX)
1%
BLEEDING RECTAL 4 EPISODES BRBPR
1%
BALANCE DISTANCE DISTURBANCE
1%
BLEEDING* HEMATURIA
1%
BLOOD IN STOOL SMALL DOT
1%
DEPRESSION, MOM'S DEATH
1%
DERMATOLOGY* ACTINIC KERATOSIS
1%
DERMATOLOGY* ANAL SKIN TAG REMOVED
1%
COUGH* DRY
1%
BPH
1%
BLOOD IN STOOL BURGUNDY
1%
CAD
1%
CARDIAC* MYOCARDIAL INFARCTION BY EKG
1%
CARDIAC* HEART PALPITATIONS AND HYPERTENSION
1%
CARDIAC* MILD AORTIC SCLEROSIS
1%
CARDIAC* VASOVAGAL EPISODE
1%
CENTRAL NERVOUS SYSTEM INCREASE IN SEIZURES
1%
DERMATOLOGY* DERMATITIS/ EXACERBATION THUMBS
1%
DERMATOLOGY* MELANOMA UPPER ARM MOLE SKIN EXCISION
1%
DERMATOLOGY* IMPETIGO (NOSE)
1%
DERMATOLOGY* FUNGAL INF.
1%
DIAPHORESIS ABDOMINAL DISCOMFORT
1%
DIARRHEA 3 EPISODES
1%
DIVERTICULITIS
1%
DIARRHEA LOOSER STOOL
1%
DIZZINESS FELL R/T LIGHT HEADED
1%
ELEVATED CREATININE BUN
1%
DIARRHEA + ABDOMINAL CRAMPS
1%
DIZZINESS/VERTIGO
1%
EAR INFECTION
1%
ELECT. BALANCE
1%
ELEVATED BLOOD PRESSURE
1%
HEARING HEARING LOSS - SIGNIFICANT OTHER PERCEPTION
1%
EXCISED MASS
1%
HYPERTENSION MILD/MOD
1%
HEARING OTOTOXICITY
1%
HEARING RIGHT EAR "PLUGGED" X2 EPISODES
1%
FLU INFECTION
1%
FX RT GREAT TOE
1%
GI BLOATING
1%
GI HEARTBURN 1 - 2 EPISODES/WEEK
1%
GI ESOPHAGEAL FULLNESS RELATED TO GASTRO CIRCLAGE
1%
GI HEARTBURN 4 EPISODES WEEKLY
1%
GI HEARTBURN, 1 EPISODE PER WEEK
1%
HEARING LOSS - SIGNIFICANT OTHER PERCEPTION
1%
HEADACHE PRESSURE
1%
HEADACHE SINUS PAIN
1%
HOT FLASHES
1%
HEARING AUDIOMETRIC CHANGE RIGHT EAR
1%
LABS DECREASED HGB GREATER THAN 10% FROM BASELINE
1%
LABS LOW HGB
1%
LABS PSA ELEVATION
1%
LABS PSA LEVELS INCREASED (5 TO 8 TO 11)
1%
LABS WHITE BLOOD CELLS COUNT DOWN
1%
TINNITUS VERY SLIGHT
1%
LOW BLOOD COUNT
1%
LOW BONE DENSITY
1%
MASS FOUND ON CRX
1%
MUCUS/COUGHING
1%
MUSCULOSKELETAL ACHE ARM LEFT
1%
MUSCULOSKELETAL LEFT HIP PAIN
1%
MUSCULOSKELETAL SCIATICA
1%
OCCULAR MIGRAIN
1%
OLECRANON BURSITIS
1%
ORAL HAD BUMP ON SURFACE OF TONGUE
1%
ORAL SORE NEAR RIGHT INCISOR
1%
ORAL* CANKER SORES
1%
ORAL* DRY THROAT
1%
OTHER* ARTHRALGIA LEFT SHOULDER
1%
WEAKNESS NEW - LEFT ARM
1%
OTHER* BURSITIS IN RIGHT SHOULDER
1%
OTHER* BURSITIS RIGHT SHOULDER
1%
OTHER* BURSITIS-ELBOW
1%
OTHER* EDEMA
1%
OTHER* EDEMA LEFT EXTREMITY
1%
OTHER* GU - URINARY FREQUENCY
1%
OTHER* IGA GLOMERULONEPHRITIS
1%
OTHER* INCREASED STRESS
1%
OTHER* IRRITATED THROAT
1%
OTHER* KIDNEY STONES
1%
OTHER* MUCLE PULLED BACK
1%
OTHER* OSTEOPOROSIS
1%
OTHER* POST NASAL DRIP
1%
OTHER* RIGHT GREAT TOE WITH REDDISH SPOT
1%
OTHER* RIGHT INGUINAL HERNIA
1%
OTHER* ROOT CANAL X3
1%
OTHER* RUNNY NOSE
1%
OTHER* SINUS PROBLEM
1%
OTHER* SKIN LESION LEFT FOREARM
1%
OTHER* URINARY URGENCY
1%
OTOTOXICITY* TINNITUS LEFT EAR
1%
PAIN* BACK LOWER LEFT
1%
PAIN* GREAT TOES PAINFUL
1%
PAIN* GROIN PAIN/ PUBIC BONE WITH LONG SITTING
1%
PAIN* JOINTS OF LEFT SIDE
1%
PAIN* LEFT THUMB
1%
PAIN* POST ORAL SURGERY
1%
PAIN* POST ROOT CANAL
1%
PAIN* POST SURGICAL
1%
PAIN* RIGHT GREAT TOE
1%
PAIN* RIGHT LOWER BACK AND LEFT KNEE PAIN
1%
PERIPHERAL NERVOUS SYSTEM* PARESTHESIA LEFT SHOULDER PINCHED NERVE
1%
PERIPHERAL NERVOUS SYSTEM* PERESTHESIA, FEET, INCREASED FROM BASELINE
1%
POST NASAL DRIP
1%
RASH EXACERBATION OF SEASONAL ITCHY RASH
1%
RASH URTICARIA RIGHT BUTTOCK
1%
REFLUX
1%
REFLUX ACID
1%
SKIN RASH
100%
80%
60%
40%
20%
0%
Study treatment Arm
Arm I (Eflornithine and Sulindac)
Arm II (Placebo)

Trial Design

2Treatment groups
Experimental Treatment
Group I: ExpansionExperimental Treatment2 Interventions
The expansion cohort will include up to 40 evaluable patients at a proposed RP2D level of AMXT1501 and DFMO defined by AMXT1501-101A study to further characterize safety at proposed RP2D dose level with repeat dosing, and characterize early anti-tumor activity.
Group II: EscalationExperimental Treatment2 Interventions
Dose escalation of DFMO with AMXT1501 fixed dose will follow a 3 + 3 dose escalation design. The AMXT 1501 starting dose administered in the first cohort will be 1200mg total daily dose (200 mg capsules; 3 capsules in morning; 3 capsules in evening) along with IV DFMO administered in continuous infusion at 2mL/hr over a 28 days per cycle. The patient can be treated for additional 28 day treatment cycles as deemed appropriate by their study investigator. Dose escalation of DFMO alone will increase per cohort.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
AMXT1501
2018
Completed Phase 1
~60
DFMO
2014
Completed Phase 2
~240

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.
Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Common treatments for head and neck cancers include surgery, radiation therapy, and chemotherapy. Chemotherapy often involves drugs like cisplatin, which forms DNA crosslinks and inhibits DNA synthesis, leading to cell death. Targeted therapies, such as cetuximab, inhibit the epidermal growth factor receptor (EGFR), blocking cell proliferation. Treatments like AMXT 1501 dicaprate and IV DFMO focus on inhibiting polyamine synthesis, which is crucial for cell growth and differentiation. DFMO inhibits ornithine decarboxylase, reducing polyamine levels, while AMXT 1501 dicaprate likely enhances this effect. This matters for head and neck cancer patients as targeting polyamine synthesis can potentially reduce tumor growth and improve treatment outcomes, offering a novel approach for those who may not respond well to traditional therapies.
Contradictory antitumor efficacies produced by the combination of DNA attacking drugs and polyamine antimetabolites.Antitumor-activity of orally-administered ammine amine platinum (iv) dicarboxylate complexes against a panel of human ovarian-carcinoma xenografts.Polyamine catabolism in colorectal cancer cells following treatment with oxaliplatin, 5-fluorouracil and N1, N11 diethylnorspermine.

Find a Location

Who is running the clinical trial?

Aminex Therapeutics, Inc.Lead Sponsor
3 Previous Clinical Trials
309 Total Patients Enrolled
Jackie Walling, MBChB PhDStudy ChairAminex Therapeutics, Inc.
1 Previous Clinical Trials
56 Total Patients Enrolled
Sue Lee, MDStudy ChairAminex Therapeutics, Inc.

Media Library

AMXT1501 (Other) Clinical Trial Eligibility Overview. Trial Name: NCT05500508 — Phase 1 & 2
Head and Neck Cancers Research Study Groups: Escalation, Expansion
Head and Neck Cancers Clinical Trial 2023: AMXT1501 Highlights & Side Effects. Trial Name: NCT05500508 — Phase 1 & 2
AMXT1501 (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05500508 — Phase 1 & 2
~7 spots leftby Dec 2024
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