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Tetracycline Antibiotic

Doxycycline for Acneiform Eruptions

Phase 4
Waitlist Available
Research Sponsored by Lady Davis Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights
All Individual Drugs Already Approved
Approved for 60 Other Conditions
Pivotal Trial
Drug Has Already Been Approved
No Placebo-Only Group

Summary

This trial is comparing tetracyclines to isotretinoin for treatment of moderate to severe acneiform eruptions in cancer patients on tyrosine kinase inhibitors.

Eligible Conditions
  • Acneiform Eruptions
  • Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Quantitative improvement in acneiform eruptions in cancer patients on tyrosine kinase inhibitors as defined by a change in Leeds Revised Acne Grading Scale.
Secondary study objectives
Adverse events from the study medications as defined using the CTCAE version 5.0 guidelines
Quantitative change on patient's quality of life with treatment of the acneiform eruption as measured by the dermatology life quality index scale.
Response of malignancy to cancer therapy using RECIST v1.1 guidelines

Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
Approved for 60 Other Conditions
This treatment demonstrated efficacy for 60 other conditions.
Pivotal Trial
The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
Drug Has Already Been Approved
The FDA has already approved this drug, and is just seeking more data.
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Active Control
Group I: DoxycyclineActive Control1 Intervention
Doxycycline 100mg po once daily x 6 months
Group II: IsotretinoinActive Control1 Intervention
Isotretinoin 40mg po once daily x 6 months

Find a Location

Who is running the clinical trial?

Lady Davis InstituteLead Sponsor
48 Previous Clinical Trials
6,070 Total Patients Enrolled
~24 spots leftby Nov 2025
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