← Back to Search

HLADQA1*05A>G screening for Inflammatory Bowel Disease (INHERIT Trial)

N/A
Waitlist Available
Led By Aze A Wilson, MD, PhD
Research Sponsored by Western University, Canada
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 year
Awards & highlights

Summary

This trial looks at whether a gene test can help predict who will form antibodies to a certain drug, which would then help guide clinicians in deciding whether to put patients on combination therapy.

Eligible Conditions
  • Inflammatory Bowel Disease
  • Crohn's Disease
  • Ulcerative Colitis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
incidence of infliximab anti-drug antibodies
Secondary study objectives
incidence of combination therapy (infliximab and one of methotrexate or azathioprine) -related adverse drug events
Adverse reaction to drug
incidence of infliximab discontinuation
+5 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: preemptive screeningExperimental Treatment1 Intervention
prospective HLADQA1\*05A\>G screening and targeted administration of combination therapy of infliximab with one of either methotrexate or azathioprine.
Group II: standard of careActive Control1 Intervention
administration of combination therapy with infliximab and one of methotrexate or azathioprine is at the discretion of the treating physician. HLADQA1\*05A\>G genotyping will be performed retrospectively.

Find a Location

Who is running the clinical trial?

Western University, CanadaLead Sponsor
248 Previous Clinical Trials
53,214 Total Patients Enrolled
Aze A Wilson, MD, PhDPrincipal InvestigatorWestern University
~32 spots leftby Sep 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top