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Behavioral Intervention

Cognitive Behavioral Therapy vs Acceptance and Commitment Therapy for Depression

N/A
Recruiting
Led By Iony D Ezawa, PhD
Research Sponsored by University of Southern California
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
18 years of age or older
Diagnosis of major depressive disorder (MDD) according to DSM-V criteria (APA, 2013)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up post-treatment (8-weeks) and follow-up (6-months)
Awards & highlights
No Placebo-Only Group

Summary

"This trial will compare two types of therapy, cognitive-behavioral therapy (CBT) and acceptance and commitment therapy (ACT), for major depressive disorder. The therapies will be delivered in online group

Who is the study for?
This trial is for individuals with major depressive disorder (MDD) who are comfortable receiving psychological treatment in an online group setting. Participants will be screened and evaluated to ensure they meet the study's requirements.
What is being tested?
The study compares two evidence-supported treatments for depression: Cognitive Behavioral Therapy (CBT) and Acceptance and Commitment Therapy (ACT), both delivered online over 8 weeks, with a follow-up after 6 months.
What are the potential side effects?
As CBT and ACT are psychological therapies, side effects may include temporary increases in emotional distress, as participants work through difficult issues during therapy sessions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am 18 years old or older.
Select...
I have been diagnosed with major depressive disorder.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~post-treatment (8-weeks) and follow-up (6-months)
This trial's timeline: 3 weeks for screening, Varies for treatment, and post-treatment (8-weeks) and follow-up (6-months) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Patient Health Questionnaire (PHQ-9)
Positive and Negative Affect Schedule (PANAS)
WHO Quality of Life-Brief (WHOQOL-BREF)

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Active Control
Group I: Cognitive Behavioral TherapyActive Control1 Intervention
Over 8 sessions, clients learn techniques to challenge and change maladaptive thought and behavioral patterns
Group II: Acceptance and Commitment TherapyActive Control1 Intervention
Over 8 sessions, clients learn techniques to accept their negative internal experiences and commit to action in line with their values

Find a Location

Who is running the clinical trial?

University of Southern CaliforniaLead Sponsor
944 Previous Clinical Trials
1,604,495 Total Patients Enrolled
25 Trials studying Depression
6,615 Patients Enrolled for Depression
Iony D Ezawa, PhDPrincipal InvestigatorUniversity of Southern California
1 Previous Clinical Trials
306 Total Patients Enrolled
1 Trials studying Depression
306 Patients Enrolled for Depression
~85 spots leftby Jan 2026
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