Popular Trials
Hormone Therapy
Elinzanetant for Menopausal Sleep Disturbances
This trial is testing a new medication called Elinzanetant to help women who have trouble sleeping due to menopause. The medication may help by blocking a protein that causes sleep problems. Participants will take the medication for a few months to see if it improves their sleep.
Pre-Exercise Protein for Perimenopause
This trial aims to compare the effects of high-intensity interval training (HIIT) and traditional aerobic exercise on metabolism in overweight or obese women going through perimenopause. The study will also look at how eating protein or carbohydrates before exercise affects these outcomes. The goal is to understand how these exercises and dietary choices can help manage weight and improve metabolic health during perimenopause. High-intensity interval training (HIIT) has been shown to significantly decrease body weight and fat mass, with more pronounced effects in premenopausal women.
Procedure
PRP Injections for Postmenopausal Syndrome
This trial is testing whether injections of platelet-rich plasma (PRP) into the anterior vaginal wall can improve sexual functioning in women experiencing symptoms of menopause. PRP is a solution with a high
Device
Silicone Gel vs. Estrogen Cream for Genitourinary Syndrome
This trial is testing a new treatment called StrataMGT for women experiencing Genitourinary Syndrome of Menopause (GSM). It aims to see if StrataMGT can improve their quality of life as well as the standard estrogen vaginal cream. Participants will use either StrataMGT or estrogen cream for a period of time and will be monitored regularly.
Hormone Therapy
Hormone Therapy for Menopause-Related Irritability
This trial uses an estradiol patch to help perimenopausal women with irritability by stabilizing their hormone levels. These patches have been used in various studies to treat menopausal symptoms, including hot flushes and depression, and are known for their convenience and effectiveness.
Beta-blocker
Propranolol for Vascular Responses in Menopause
"This trial aims to investigate how blood vessels widen in response to low oxygen levels and the involvement of specific receptors in women of different age groups: younger, middle-aged, and older women."
Popular Filters
Trials for Hot Flashes Patients
Behavioural Intervention
Vegan Diet + Soybeans for Hot Flashes
This trial tests if a low-fat, vegan diet with soybeans can reduce menopausal hot flashes. Women experiencing these symptoms will follow this diet for a few months. The soybeans might help lessen hot flashes by acting like estrogen. Soy has been studied for its potential to reduce menopausal hot flashes, with varying degrees of success reported in different studies.
Androgen
Intrarosa for Menopause
Tissues of the genitals of women are both androgen (testosterone) and estrogen dependent. The clitoris, vestibule, urethra, anterior vaginal wall, peri-urethral tissue, and pelvic floor all depend on androgens for normal function. In addition, the glands, which secrete lubrication during sexual arousal, also require androgens to function. Deficiencies of both estrogens and androgens occur naturally during menopause. Menopause-related deficiencies of these hormones lead to thinning in the tissues of the genital and urinary systems which have been termed Genitourinary Syndrome of Menopause (GSM). Patients with GSM will frequently complain of dryness and/or pain during sexual intercourse. Historically, GSM treatment involved both androgens and estrogens, However, over the past few decades estrogen based therapies have become much more common. More recently, clinical trials have demonstrated that local vaginal dehydroepiandrosterone (Intrarosa®) improves symptoms in menopausal women who have moderate to severe pain with intercourse. Intrarosa® vaginal inserts are a prescription medicine approved by the U.S. Food and Drug Administration (FDA) used in women after menopause to treat moderate to severe pain during sexual intercourse caused by changes in and around the vagina that happen with menopause.
Behavioral Intervention
Hot Water Therapy for Menopause-Related Hot Flashes
This trial is studying the effects of hot water therapy on menopausal women. The researchers want to see if taking hot baths for multiple days in a row can reduce hot flash symptoms and improve mood.
Probiotic
Probiotic Supplement for Menopause Symptoms
This trial tests if a probiotic supplement can reduce menopause symptoms like hot flashes, night sweats, mood swings, etc. Participants take a test product or placebo daily and provide data on weight, waist, sleep, and symptoms.
Phytoestrogenic Supplement
PhytoSERM for Menopause-related Cognitive Impairment
This trial tests PhytoSERM, a plant-based supplement that mimics estrogen, in peri- and postmenopausal women. The goal is to see if it helps the brain use glucose better, potentially improving brain function and reducing menopausal symptoms. Participants will take the supplement for several months, with brain scans before and after to measure effects. PhytoSERM is a formulation of genistein, daidzein, and S-equol that may enhance neuron function and estrogenic mechanisms in the brain.
Trials for Insomnia Patients
Hormone Therapy
Melatonin for Insomnia
This trial tests a slow-release melatonin pill to help postmenopausal women with sleep problems. The pill works by mimicking the body's natural sleep hormone to regulate sleep patterns. Melatonin has been studied extensively for its sleep-promoting effects in various populations, including the elderly and those with sleep disorders.
Androgen
Intrarosa for Menopause
Tissues of the genitals of women are both androgen (testosterone) and estrogen dependent. The clitoris, vestibule, urethra, anterior vaginal wall, peri-urethral tissue, and pelvic floor all depend on androgens for normal function. In addition, the glands, which secrete lubrication during sexual arousal, also require androgens to function. Deficiencies of both estrogens and androgens occur naturally during menopause. Menopause-related deficiencies of these hormones lead to thinning in the tissues of the genital and urinary systems which have been termed Genitourinary Syndrome of Menopause (GSM). Patients with GSM will frequently complain of dryness and/or pain during sexual intercourse. Historically, GSM treatment involved both androgens and estrogens, However, over the past few decades estrogen based therapies have become much more common. More recently, clinical trials have demonstrated that local vaginal dehydroepiandrosterone (Intrarosa®) improves symptoms in menopausal women who have moderate to severe pain with intercourse. Intrarosa® vaginal inserts are a prescription medicine approved by the U.S. Food and Drug Administration (FDA) used in women after menopause to treat moderate to severe pain during sexual intercourse caused by changes in and around the vagina that happen with menopause.
Behavioral Intervention
Hot Water Therapy for Menopause-Related Hot Flashes
This trial is studying the effects of hot water therapy on menopausal women. The researchers want to see if taking hot baths for multiple days in a row can reduce hot flash symptoms and improve mood.
Probiotic
Probiotic Supplement for Menopause Symptoms
This trial tests if a probiotic supplement can reduce menopause symptoms like hot flashes, night sweats, mood swings, etc. Participants take a test product or placebo daily and provide data on weight, waist, sleep, and symptoms.
Phytoestrogenic Supplement
PhytoSERM for Menopause-related Cognitive Impairment
This trial tests PhytoSERM, a plant-based supplement that mimics estrogen, in peri- and postmenopausal women. The goal is to see if it helps the brain use glucose better, potentially improving brain function and reducing menopausal symptoms. Participants will take the supplement for several months, with brain scans before and after to measure effects. PhytoSERM is a formulation of genistein, daidzein, and S-equol that may enhance neuron function and estrogenic mechanisms in the brain.
Trials With No Placebo
Behavioural Intervention
MyMenoPlan for Menopause
As part of a National Institute on Aging -funded R01, the investigators developed an evidence-based, multi-media digital resource entitled MyMenoPlan to help women learn about the menopause transition, and the symptoms and treatments of perimenopause/menopause. MyMenoPlan is also designed to help women learn about the effectiveness of treatments for a comprehensive list of midlife symptoms and compare treatments that may help with the specific symptoms women are experiencing.
Behavioural Intervention
Cognitive Behavioural Therapy for Perimenopause
This trial is testing a new CBT protocol specifically designed to help with sexual concerns during perimenopause. The aim is to see if it improves sexual satisfaction and reduces distress.
Behavioural Intervention
Vegan Diet + Soybeans for Hot Flashes
This trial tests if a low-fat, vegan diet with soybeans can reduce menopausal hot flashes. Women experiencing these symptoms will follow this diet for a few months. The soybeans might help lessen hot flashes by acting like estrogen. Soy has been studied for its potential to reduce menopausal hot flashes, with varying degrees of success reported in different studies.
Cholinergic Antagonist for Postmenopausal Cognitive Decline
This trial will study how changes in hormones after menopause may interact with the cholinergic system (which is involved in memory and other cognitive functions) to influence a woman's risk for cognitive decline.
View More Related Trials
Frequently Asked Questions
Introduction to menopause
What are the top hospitals conducting menopause research?
While menopause is a natural phase in every woman's life, it can come with its fair share of challenges. That's why hospitals across the globe are conducting clinical trials to better understand and alleviate symptoms associated with this transitional period. In Burlington, Vermont, the University of Vermont leads the way with three ongoing menopause trials. Although they have yet to record any completed studies specifically focused on menopause, their commitment to research brings hope for future breakthroughs in managing this stage of life. Meanwhile, Helix Biomedics in Boynton Beach is also actively engaged in two menopause trials as part of their dedication to advancing women's health through scientific exploration.
In New Port Richey, Florida, Suncoast Clinical Research Center joins the ranks by conducting two active clinical trials related to menopause. With zero previous studies completed thus far within this particular scope, their current efforts demonstrate a growing focus on addressing key concerns faced by women during this significant hormonal shift.
Further south in Houston, Texas; Advances in Health Inc., contributes significantly as well by carrying out two ongoing clinical investigations focusing solely on understanding and improving quality-of-life aspects regarding Menopausal patients.To date,no such experiments were concluded but progress arising from these endeavors holds promise for those experiencing difficulties during this transformative period.
Moreover Ottawa Hospital-Riverside Campus located at Canada’s capital city ,Ottawa also emerges an important player where there are around 2 ongoing tests aiming towards comprehending various dimensions surrounding Menopausal experience.In contrasts similarly like above mentioned locations no past trial has been recorded so far.However signifying collective effort made globally,taken together,the contributions from these hospitals reflect a shared commitment among medical professionals worldwide toward enhancing our knowledge about menopause and offering potential solutions that could empower millions of women navigating this crucial phase of life
Which are the best cities for menopause clinical trials?
When it comes to menopause clinical trials, several cities emerge as top destinations for cutting-edge research. Raleigh in North carolina leads the way with 6 active trials investigating treatments like Elinzanetant (BAY3427080) and FP-101. Boston, Massachusetts follows closely behind with 5 ongoing studies focused on various interventions including suvorexant. Washington, D.C., Mesa in Arizona, and Las Vegas in Nevada each offer 4 active trials examining potential breakthroughs such as Elinzanetant (BAY3427080) and other interventions. These cities provide individuals seeking solutions for menopause-related symptoms access to a range of clinical trials that could shape the future of menopausal care.
Which are the top treatments for menopause being explored in clinical trials?
Clinical trials are actively investigating various treatments for menopause, aiming to provide relief and improve quality of life. Among the top contenders are:
- Hormone replacement therapy (HRT): A well-established treatment that seeks to replace hormones lost during menopause.
- Non-hormonal therapies: Approaches such as selective estrogen receptor modulators (SERMs) and medications targeting specific symptoms like hot flashes or vaginal dryness.
- Complementary and alternative medicine: Natural remedies, acupuncture, and herbal supplements that promise symptom alleviation without hormonal intervention.
What are the most recent clinical trials for menopause?
Recent clinical trials have brought new insights and potential treatments for menopause. One of these studies focused on the PhytoSERM group, which aims to address menopausal symptoms through natural compounds. Another trial investigated the use of suvorexant, a medication that targets insomnia associated with menopause. Additionally, research has explored the benefits of an extended-release transdermal film containing estradiol to alleviate symptoms. A GnRH antagonist was also studied as a possible treatment option during this transitional phase in women's lives. Lastly, the efficacy of elinzanetant (BAY3427080) is being assessed in relieving various menopausal symptoms such as hot flashes and night sweats. These recent findings bring hope for improved management and quality of life for individuals experiencing menopause.
What menopause clinical trials were recently completed?
In November 2018, a clinical trial investigating the efficacy of Transdermal Estrogen in managing menopause symptoms reached completion. Sponsored by Children's Hospital Medical Center in Cincinnati, this study contributes valuable insights into potential treatments for women experiencing menopause.