Popular Trials
Sleep Management for Nicotine Addiction
This trial will test the hypothesis that chronotype (preference for morning or evening activity) and impaired sleep impact cigarette usage, smoking dependence, urge/craving, and withdrawal differently in blacks compared to whites.
Behavioural Intervention
Integrated Treatment for Smoking Cessation After Acute Coronary Syndrome
This trial will test whether a single, integrated treatment that targets both depressed mood and smoking is more effective than usual care in reducing post-acute coronary syndrome mortality.
Nicotinic Receptor Partial Agonist
CHANTIX (Varenicline) for Smoking Cessation after Acute Coronary Syndrome
This trial looks at the role of a nicotine antagonist in helping patients who have had a heart attack or other acute coronary syndrome to stop smoking.
Electronic Cigarette
E-Cigarettes + NRT and Counseling for Smoking in Opioid Use Disorder
This trial will compare e-cigarettes with NRT + counseling to help reduce smoking among people in opioid use disorder treatment. It will help provide a tool to reduce tobacco harm in a hard-to-treat population.
Popular Filters
Trials for Smoking Cessation Patients
Behavioural Intervention
TMS for Smoking Cessation in Schizophrenia
This trial uses a magnetic pulse device to help people with schizophrenia stop smoking. It targets specific brain areas involved in both conditions. The goal is to see if this method is effective for this particular group. This method has been shown to decrease cigarette consumption in schizophrenia patients.
Behavioral Intervention
Smoke-Free Policy Support for Smoking Cessation
This trial will test two ways to reduce exposure to secondhand smoke in residential buildings. One targets all building residents, while the other targets smokers specifically, with the goal of reducing smoking and exposure to secondhand smoke.
Behavioural Intervention
Motivational Interviewing (MI) +1 More for Smoking Cessation
The Pennsylvania Adolescent Smoking Study (PASStudy) will evaluate the effectiveness of Motivational Interviewing (MI) compared to Structured Brief Advice (SBA) to reduce cigarette smoking among adolescents who smoke. MI is a brief 5 session client-centered psychotherapeutic style intended to increase "the probability that a person will enter into, continue and adhere to a specific change strategy." This will be compared with SBA, which implements Best Practice Guidelines (i.e., 5 A's and 5 R's) and assists participants in accessing the best available resources for smoking cessation.
Behavioural Intervention
Smoking Cessation Treatment for Head & Neck Cancer Patients
This trial is designed to study and compare the effectiveness of two types of counseling for cancer patients who want to quit smoking: Acceptance and Commitment Therapy (ACT) and Motivational and Behavioral Counseling (MBC).
Improved module for Smoking Cessation
This pilot study will determine the feasibility of studying a new smoking cessation management module in an existing chronic disease management system. The new module is intended to help healthcare providers deliver more smoking cessation counselling to their patients.
Trials for Tobacco Smoking Patients
NMDA Receptor Antagonist
Ketamine vs Midazolam for Tobacco Use Disorder
This trial tests how different drugs affect smoking habits and cravings in people who are not trying to quit. Participants receive an injection of either ketamine, midazolam, dexmedetomidine, or a saltwater solution. The study aims to see if these drugs can help reduce cravings and withdrawal symptoms.
Behavioral Intervention
Motivational Interviewing/CBT for Smoking/Cigarette Smoking
The purpose of this study is to determine the extent to which an Intentional Behavioral Intervention will increase tobacco quit rates post release among incarcerated men and women.
Behavioral Intervention
Effect of Packaging on Smoking Perceptions and Behavior for Smoking
The investigators are addressing two critical areas identified by the FDA: the impact of cigarette packaging and labeling on consumer perceptions and on smoking behavior; and the effectiveness of graphic warning labels on communicating risk of tobacco products. In a randomized controlled trial (RCT), investigators will enroll committed smokers who have no intention of quitting in the next 6-months. The three study arms will be: a) a blank pack with all marketing materials removed (PP); b) The Australian graphic warning images (Australian model-AM); or c) a standard pack with all marketing materials unaltered (ST). The study includes a three month purchasing intervention and continued follow-up through 12 months. Throughout the study interactive text messaging assessments will be used to measure acute and persistent impact of labeling and marketing on perceptions of tobacco products, subjective effects of consumption, awareness of tobacco-related harms, tobacco use behavior, and quitting motivation. At three separate time points, participants will: a) complete a web-based questionnaire b) provide a saliva sample for cotinine analysis. The rigorous design and extensive objective measurements are significant innovations on the currently published research in this field and should lead to significant advances in tobacco regulatory science.
Smoking Cessation Agent
Varenicline for Tardive Dyskinesia
To test the feasibility of studying effects of smoking cessation with varenicline on antipsychotic drug-induced neurological side effects, we propose a 12 week pilot study of smoking cessation treatment with varenicline in 10 schizophrenia or schizoaffective disorder patients who are actively smoking and have pre-existing TD while receiving stable doses of antipsychotics. Subjects will be followed after a 2 week baseline period to assess changes in smoking status and neurological symptoms using standardized rating scales. The aim is to examine clinically significant effects on antipsychotic-induced neurological side effects that may warrant further investigation.
Phase 3 Trials
Behavioral Intervention
DVD Intervention for Smoking
The purpose of this study is to determine if a newly designed DVD program performs better than standard, printed quit-smoking materials to help smokers who have mobility limitations (e.g., use a cane, wheelchair, braces, crutches, prosthesis) to quit smoking.
Behavioral Intervention
Withdrawal Regulation Training for Smoking Cessation
This trial will test a new smoking cessation treatment to see if it is effective and how it works. The results could help improve existing treatments and reduce smoking-related deaths in the US.
Trials With No Placebo
NMDA Receptor Antagonist
Ketamine vs Midazolam for Tobacco Use Disorder
This trial tests how different drugs affect smoking habits and cravings in people who are not trying to quit. Participants receive an injection of either ketamine, midazolam, dexmedetomidine, or a saltwater solution. The study aims to see if these drugs can help reduce cravings and withdrawal symptoms.
Behavioural Intervention
TMS for Smoking Cessation in Schizophrenia
This trial uses a magnetic pulse device to help people with schizophrenia stop smoking. It targets specific brain areas involved in both conditions. The goal is to see if this method is effective for this particular group. This method has been shown to decrease cigarette consumption in schizophrenia patients.
Behavioral Intervention
Smoke-Free Policy Support for Smoking Cessation
This trial will test two ways to reduce exposure to secondhand smoke in residential buildings. One targets all building residents, while the other targets smokers specifically, with the goal of reducing smoking and exposure to secondhand smoke.
View More Related Trials
Frequently Asked Questions
Introduction to smoking
What are the top hospitals conducting smoking research?
When it comes to tackling the complex issue of smoking, several top hospitals are at the forefront of conducting groundbreaking clinical trials. In Houston, M D Anderson Cancer Center leads the charge with eight active smoking trials aimed at understanding and addressing this harmful addiction. Interestingly, this renowned institution has not conducted any previous smoking trials, highlighting their commitment to pushing boundaries and exploring new avenues in research. Similarly, Brown University School of Public Health in Providence is actively involved in three ongoing smoking trials but does not have a historical record of conducting such studies. This signifies their dedication to making significant strides forward in combating smoking-related issues.
In Philadelphia, the University of Pennsylvania is also playing a vital role by currently running three active clinical trials focused on smoking cessation and related concerns. Like the previous institutions mentioned above, they have yet to conduct any past studies specifically targeting smoking. Meanwhile, another prominent Houston-based hospital named University of Texas MD Anderson Cancer Center is actively engaged in three ongoing smoking trials as well.
Last but certainly not least, the Medical University of South carolina located in Charleston is lending its expertise towards combating tobacco addiction through three current clinical trials dedicated to understanding various aspects surrounding this global health concern.
These esteemed medical centers shed light on an important aspect: while there may be no historical records for these institutions' involvement with specific types of research like cigarette-smoking-related investigations up until now; their ongoing efforts demonstrate an unwavering commitment towards exploring innovative solutions that could potentially transform how we approach issues associated with tobacco use disorder.
Which are the best cities for smoking clinical trials?
When it comes to smoking clinical trials, several cities have emerged as key players in research and development. Houston, Texas takes the lead with 19 active trials focusing on the effects of cigarettes, nicotine replacement therapies (NRT), and innovative interventions like the MASP app combined with NRT. Miami, Florida follows closely behind with 15 ongoing studies examining cigarette use and treatment options such as cisplatin. Honolulu, Hawaii also contributes to this field with eight active trials investigating cisplatin's impact on smoking cessation. These cities provide individuals interested in participating in smoking-related clinical trials access to cutting-edge research that aims to improve tobacco cessation strategies and reduce associated health risks.
Which are the top treatments for smoking being explored in clinical trials?
Several potential breakthroughs are being investigated in clinical trials to combat smoking addiction. Leading the pack is varenicline, a medication that has shown promise with its effectiveness and safety profile. Also making waves is cytisine, an affordable and accessible treatment option that holds significant potential for smoking cessation. Finally, nicotine replacement therapies (NRTs) such as patches, gum, and lozenges continue to be explored for their efficacy in helping individuals quit smoking. These innovative treatments offer hope for smokers looking to break free from addiction and improve their overall health and well-being.
What are the most recent clinical trials for smoking?
Recent clinical trials are shedding light on innovative approaches to address smoking addiction. One such study involves active rTMS, a non-invasive brain stimulation technique that shows promise in aiding individuals who want to quit smoking. Additionally, research is underway to understand the optimal timing for initiating nicotine replacement therapy as part of standard treatment for smoking cessation. Another trial focuses on contingency management strategies that provide incentives to encourage smokers towards quitting. With these advancements, healthcare professionals can offer more effective interventions and support those struggling with tobacco addiction on their journey towards better health.
What smoking clinical trials were recently completed?
In recent times, there have been several completed clinical trials focused on smoking cessation. These trials aimed to explore various strategies and interventions to assist individuals in quitting smoking. While the specific details of these trials may vary, their common goal was to contribute to our understanding of effective approaches for tobacco addiction treatment. By evaluating different methods and interventions, researchers strive to improve smoking cessation outcomes and ultimately reduce the harmful impact of tobacco use on public health.