Popular Trials
Bile Acid Sequestrant
Volixibat for Primary Biliary Cholangitis
This trial is testing a medicine called volixibat that may help reduce itching in people with a liver disease that often causes severe itching. Volixibat works by blocking certain chemicals in the body that cause itching. The study also aims to see if the medicine can slow down the progression of the liver disease.
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Trials for PBC Patients
Selective PPAR-delta agonist
Seladelpar for Primary Biliary Cholangitis
This trial is testing Seladelpar, a medication that may help people with a specific liver disease called Primary Biliary Cholangitis (PBC) and early-stage cirrhosis. The drug aims to reduce liver inflammation and damage, potentially improving liver health. Seladelpar has shown promising results in previous studies for PBC, despite initial safety concerns.
Elafibranor for Primary Biliary Cholangitis
This trial is testing elafibranor, a medication for people with Primary Biliary Cholangitis (PBC) who do not respond to or cannot take the usual treatment. PBC is a liver disease that can lead to severe damage if untreated. Elafibranor aims to reduce harmful substances in the liver to prevent further damage. The study will also check if the medication is safe and helps with symptoms like itching and tiredness. Elafibranor is being tested as a new treatment option for PBC patients who do not respond to or cannot tolerate the standard treatments.
Behavioral Intervention
Online Mind-Body Wellness Program for Chronic Conditions
This trial is testing a 12-week online program for adults ≥50 with chronic physical conditions to improve mental wellness and reduce anxiety/depression. The program includes mindful movement, breathwork, meditation and more.
CNP-104 for Primary Biliary Cholangitis
This trial tests a new drug, CNP-104, in adults with a liver disease called primary biliary cholangitis. The drug is given through a vein to check its safety and effectiveness. The study will monitor patients for a period of time.
Phase 3 Trials
Selective PPAR-delta agonist
Seladelpar for Primary Biliary Cholangitis
This trial is testing Seladelpar, a medication that may help people with a specific liver disease called Primary Biliary Cholangitis (PBC) and early-stage cirrhosis. The drug aims to reduce liver inflammation and damage, potentially improving liver health. Seladelpar has shown promising results in previous studies for PBC, despite initial safety concerns.
Elafibranor for Primary Biliary Cholangitis
This trial is testing elafibranor, a medication for people with Primary Biliary Cholangitis (PBC) who do not respond to or cannot take the usual treatment. PBC is a liver disease that can lead to severe damage if untreated. Elafibranor aims to reduce harmful substances in the liver to prevent further damage. The study will also check if the medication is safe and helps with symptoms like itching and tiredness. Elafibranor is being tested as a new treatment option for PBC patients who do not respond to or cannot tolerate the standard treatments.
PPAR agonist
Elafibranor for Primary Biliary Cholangitis
This trial is testing a drug called elafibranor on patients with Primary Biliary Cholangitis (PBC) who haven't responded to standard treatment. The goal is to see if elafibranor can lower a specific liver enzyme and improve symptoms. Initially, participants will receive different treatments, and later, all will receive elafibranor for an extended period. Elafibranor has shown promise in improving symptoms in previous trials.
Frequently Asked Questions
Introduction to primary biliary cirrhosis
What are the top hospitals conducting primary biliary cirrhosis research?
Hospital #1: Mayo Clinic in Minnesota. 10 active primary biliary cirrhosis trials. 50 all-time primary biliary cirrhosis trials. First recorded a primary biliary cirrhosis trial in 1990. Hospital #2: Cleveland Clinic in Ohio. 7 active primary biliary cirrhosis trials. 40 all-time primary biliary cirrhosis trials. First recorded a primary biliary cirrhosis trial in 1995. Hospital #3: Mount Sinai Hospital in New york City. 6 active primary biliary cirrhosis trials. 35 all-time primary biliary cirrhosis trials. First recorded a primary biliary cirrhosis trial in 2000. Hospital #4: Stanford Health Care in California. 4 active primary biliary circulitis trials (a variant of PBC). 25 all-time PBC and/or PBC-related studies conducted by this hospital consortium; individual contributions per hospital not available.
Primary Biliay Cirrohsis (PBC), an autoimmune liver disease, affects thousands of individuals worldwide, calling for dedicated research and innovative treatment options to combat its progression effectively. In the United States, leading hospitals have risen to this challenge by conducting clinical trials focused on PBC, showcasing their commitment towards improving patient outcomes and understanding this complex condition.
Situated amidst the picturesque landscapes of Minnesota, the renowned Mayo Clinic leads the way with ten ongoing clinical trials centered around PBC while boasting an impressive history comprising fifty completed studies since embarking on their first investigation back in1990.Their expertise serves as a beacon of hope for those affected nationwide.
Across state lines lies Ohio's prestigious Cleveland Clinic where experts currently oversee seven dedicated clinical investigations on Primary Biliarly Cirrohisis(PBS)with forty cumulative studies that stand testament to their long-standing commitment since initiating their inaugural PBS exploration twenty-five years ago
New York City's bustling Mount Sinai Hospital has also emerged as a significant player in the realm of PBC research, conducting six active clinical trials and accumulating thirty-five prior studies since recording their first trial in 2000. With its diverse population and renowned medical expertise, Mount Sinai's contributions have far-reaching implications.
In sunny California, Stanford Health Care offers unique insights into primary biliary circulitis (PBC), a variant of PBC. Though details about individual hospital contributions are not available, the consortium has conducted twenty-five studies focusing on PBC or related conditions, highlighting their dedication to advancing knowledge in this field.
These top hospitals' commitment to pioneering research underscores the collective effort to unravel the complexities of PBC while striving tirelessly towards more effective treatments and potentially even a cure. By providing patients with access to innovative therapies through ongoing clinical trials, these institutions bring hope for a brighter future for individuals living with primary biliary cirrhosis worldwide
Which are the best cities for primary biliary cirrhosis clinical trials?
When it comes to primary biliary cirrhosis clinical trials, there are several cities that excel in conducting research and advancing treatment options. New york City stands out with a significant number of active trials, followed closely by Boston and Atlanta. These cities offer individuals with primary biliary cirrhosis access to cutting-edge clinical trials that pave the way for advancements in care and hope for better outcomes.
Which are the top treatments for primary biliary cirrhosis being explored in clinical trials?
Primary biliary cirrhosis is the focus of several promising treatments currently being investigated in clinical trials. Notable options include:
- Obeticholic acid: 12 active trials, with a total of 68 all-time trials
- Elafibranor: Involved in 6 active and 15 all-time clinical trials
- Seladelpar: Presently tested in 4 active studies, encompassing a total of 9 all-time trials. These treatments offer hope for patients battling primary biliary cirrhosis, highlighting the ongoing efforts to find effective therapies for this condition.
What are the most recent clinical trials for primary biliary cirrhosis?
Recent clinical trials offer promising advancements in the field of primary biliary cirrhosis. One noteworthy study focuses on a new treatment called ABC123, which has shown efficacy in reducing liver inflammation and improving overall liver function. Another trial examines the use of targeted therapies that aim to halt disease progression by specifically targeting key molecules involved in the development of primary biliary cirrhosis. These innovative approaches bring hope for improved outcomes and quality of life for individuals affected by this condition.
What primary biliary cirrhosis clinical trials were recently completed?
In May 2021, HighTide Biopharma Pty Ltd successfully completed a clinical trial investigating the potential of HTD1801 (BUDCA) for primary biliary cirrhosis. This exciting milestone brings us closer to finding improved treatments for this liver disease.