Popular Trials
Antidepressant
Bupropion for Depression
Recruiting2 awardsPhase 4
Bridgewater, New Jersey
This trial tests a new treatment for children with depression. The effectiveness is measured by changes in depression symptoms. Fluoxetine has been shown to be effective in treating major depressive disorder in children and adolescents.
Behavioural Intervention
Contrave for Weight Maintenance in Obesity
Recruiting4 awardsPhase 4
Guelph, Ontario
This trial tests if Contrave, a weight-loss pill, helps maintain and further weight loss in obese or overweight adults who have already lost some weight through a diet program. The pill works by reducing hunger and increasing satisfaction with less food. Contrave is a combination of naltrexone and bupropion, developed by Orexigen Therapeutics Inc, and has shown moderate weight loss in previous studies.
Contrave for Post-Bariatric Surgery Weight Management
Recruiting4 awardsPhase 4
Guelph, Ontario
This trial is testing Contrave, a weight management pill, in adults who had bariatric surgery but are struggling with weight loss or regaining weight. The pill helps reduce hunger and increase feelings of fullness. Contrave, a combination of bupropion and naltrexone, was approved for chronic weight management in obese adults and has shown effectiveness in reducing food intake. The study will compare the effects of Contrave combined with usual care to usual care alone.
Anti-obesity agent
Drug + Behavioral Weight Loss for Obesity
Recruiting1 awardPhase 2
Baltimore, Maryland
This trial tests a weight loss medication and a remote coaching program to help overweight or obese breast cancer survivors lose weight. Participants receive phone support from a coach, and those who don't lose enough weight will start taking the medication. The study aims to see if this approach helps with weight loss and improves health markers.
Popular Filters
Phase 3 Trials
Behavioral Intervention
Tailored behavioral intervention +6 More for Nicotine Addiction
Recruiting4 awardsPhase 3
Iowa City, Iowa
The project is designed to examine the effectiveness of strategies to increase access to treatment for tobacco use and dependence among rural Veteran smokers. In addition, it will examine whether tailored treatment that is designed to address common comorbid conditions that are related to cigarette smoking enhances success with quitting relative to enhanced standard of care. The investigators hypothesize that participants assigned to the tailored tobacco cessation intervention will report greater cessation rates at six months. The investigators also anticipate more favorable outcomes on measures of depressive symptoms, alcohol use, and body weight.
Combination Drug
Medication + Behavioral Therapy for Post-Bariatric Surgery Weight Control
Recruiting2 awardsPhase 2 & 3
New Haven, Connecticut
This trial will test different treatments for people who have trouble controlling their eating and weight after weight-loss surgery. The treatments include behavior therapy to change eating habits and a combination of two medications to reduce cravings. The goal is to find out which approach works best for these patients.
Zonisamide + Bupropion for Smoking Cessation
Recruiting3 awardsPhase 3
Charlotte, North Carolina
This trial will evaluate the impact of combining zonisamide and bupropion on the process of switching from CCs to an e-cigarette. There will be a data collection period of at least five days to obtain baseline information on the use of CCs. All participants enrolled in the study will receive a JUUL e-cigarette at Visit 2 for ad libitum use. After the first week of e-cigarette use (at Visit 3), participants will be given bupropion (150 mg each morning for days 1-3, then 300 mg daily) with either zonisamide (100 mg daily) or placebo (group 1 and
Behavioral Intervention
Pharmacological and Behavioral Treatment for Obesity After Bariatric Surgery
Recruiting0 awardsPhase 2 & 3
New Haven, Connecticut
This trial tests a special program and two medications to help people lose weight after weight-loss surgery. It targets patients who still struggle with obesity despite having surgery. The program helps change daily habits, while the medications reduce hunger and cravings.
Trials With No Placebo
Kinase Inhibitor
Encorafenib +1 More for Melanoma
Recruiting1 awardPhase 1
Fountain Valley, California
This trial is testing how well a combination of two drugs, encorafenib and binimetinib, works at different doses in people with cancer. The trial will also look at how well a third drug, modafinil, works with the combination of encorafenib and binimetinib.
Smoking Cessation Aid
Varenicline +11 More for Smokeless Tobacco
Recruiting3 awards7 criteria
Iowa City, Iowa
This is a pilot study designed in an effort to develop and improve access to effective treatments for tobacco use in rural Veterans using a tailored intervention approach. Specifically, we will evaluate a combined behavioral and pharmacological smokeless tobacco cessation which concomitantly addresses comorbid issues commonly experienced by rural tobacco users including elevated depressive symptoms, risky alcohol use, and concerns about weight gain. The objectives are to: 1. Evaluate the feasibility of an individually-tailored telephone intervention for rural smokeless tobacco users 2. Examine the impact of the intervention on treatment utilization, patient satisfaction, and smokeless tobacco cessation.
Behavioral Intervention
Tailored behavioral intervention +6 More for Nicotine Addiction
Recruiting4 awardsPhase 3
Iowa City, Iowa
The project is designed to examine the effectiveness of strategies to increase access to treatment for tobacco use and dependence among rural Veteran smokers. In addition, it will examine whether tailored treatment that is designed to address common comorbid conditions that are related to cigarette smoking enhances success with quitting relative to enhanced standard of care. The investigators hypothesize that participants assigned to the tailored tobacco cessation intervention will report greater cessation rates at six months. The investigators also anticipate more favorable outcomes on measures of depressive symptoms, alcohol use, and body weight.
Behavioural Intervention
Antidepressant Treatment +1 More for Depression
Recruiting5 awardsPhase 4
Nashville, Tennessee
This study will determine whether there are age-related differences in the body systems controlling sleep and stress hormone patterns. This study will also determine whether the differences in sleep and hormone patterns between depressed adolescents and adults are associated with differences in their response to antidepressant treatment.
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Frequently Asked Questions
Do I need insurance to participate in a trial?
Almost all clinical trials will cover the cost of the 'trial drug' — so no insurance is required for this. For trials where this trial drug is given alongside an already-approved medication, there may be a cost (which your insurance would normally cover).
Is there any support for travel costs?
Many of the teams running clinical trials will cover the cost of transportation to-and-from their care center.
Will I know what medication I am taking?
This depends on the specific study. If you're worried about receiving a placebo, you can actively filter out these trials using our search.
How long do clinical trials last?
Some trials will only require a single visit, while others will continue until your disease returns. It's fairly common for a trial to last somewhere between 1 and 6 months.
Do you verify all the trials on your website?
All of the trials listed on Power have been formally registered with the US Food and Drug Administration. Beyond this, some trials on Power have been formally 'verified' if the team behind the trial has completed an additional level of verification with our team.
How quickly will I hear back from a clinical trial?
Sadly, this response time can take anywhere from 6 hours to 2 weeks. We're working hard to speed up how quickly you hear back — in general, verified trials respond to patients within a few days.