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Benzodiazepine

Lorazepam 1Mg Tablet for Ativan

Phase < 1
Waitlist Available
Led By Juan A Gallego, MD
Research Sponsored by Northwell Health
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 weeks
Awards & highlights

Summary

This trial studies how lorazepam, a common anxiety and sleep medication, affects brain connectivity in people undergoing brain scans. The researchers believe lorazepam will improve communication between different brain regions.

Eligible Conditions
  • Ativan
  • Neuroimaging

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
To understand the impact of lorazepam on functional connectivity measures collected using resting state functional magnetic imaging (rs-fMRI).
Secondary study objectives
The goal is to study the impact of lorazepam on glutamate, glutamine and GABA in the striatum.

Side effects data

From 2021 Phase 4 trial • 88 Patients • NCT03012815
2%
Allergic reaction
100%
80%
60%
40%
20%
0%
Study treatment Arm
Gabapentin
Benzodiazepine

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Lorazepam firstExperimental Treatment2 Interventions
This arm comprises of participants who were randomized to receive lorazepam 1 mg prior to the first MRI scan and then placebo on the second MRI scan a week later.
Group II: Placebo firstPlacebo Group2 Interventions
This arm comprises of participants who were randomized to receive placebo prior to the first MRI scan and then lorazepam 1 mg orally prior to the second MRI scan a week later.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Placebo
1995
Completed Phase 3
~2670

Find a Location

Who is running the clinical trial?

Northwell HealthLead Sponsor
473 Previous Clinical Trials
472,272 Total Patients Enrolled
Juan A Gallego, MDPrincipal InvestigatorNorthwell Health
~0 spots leftby Sep 2025
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