← Back to Search

Antisense Oligonucleotide

Mild hepatic impairment patients for Liver disease

Phase 1
Waitlist Available
Research Sponsored by Novartis Pharmaceuticals
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 1 (0 hour (pre-dose) 0.5 hour, 1 hour, 1.5 hour, 2 hour, 3 hour, 4 hour, 6 hour, 8 hour, 12 hour), day 2, day 3, day 4, day 8, day 30 and day 60
Awards & highlights
No Placebo-Only Group

Summary

This trial tests how a single injection of pelacarsen behaves in people with mild liver problems. Researchers want to see how the drug is absorbed, distributed, and eliminated from the body.

Eligible Conditions
  • Liver disease

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 1 (0 hour (pre-dose) 0.5 hour, 1 hour, 1.5 hour, 2 hour, 3 hour, 4 hour, 6 hour, 8 hour, 12 hour), day 2, day 3, day 4, day 8, day 30 and day 60
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 1 (0 hour (pre-dose) 0.5 hour, 1 hour, 1.5 hour, 2 hour, 3 hour, 4 hour, 6 hour, 8 hour, 12 hour), day 2, day 3, day 4, day 8, day 30 and day 60 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Pharmacokinetic parameters of pelacarsen: AUCinf
Pharmacokinetic parameters of pelacarsen: AUClast
Pharmacokinetic parameters of pelacarsen: Cmax

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Group I: Mild hepatic impairment patientsExperimental Treatment1 Intervention
Participants with mild hepatic impairment
Group II: Healthy participantsExperimental Treatment1 Intervention
Matched healthy participants with normal hepatic function
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Pelacarsen
2018
Completed Phase 1
~50

Find a Location

Who is running the clinical trial?

Novartis PharmaceuticalsLead Sponsor
2,905 Previous Clinical Trials
4,208,098 Total Patients Enrolled
~4 spots leftby Nov 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top