Deep Brain Stimulation for Parkinson's Disease

N/A

Recruiting

Led By Kiarash Shahlaie, MD, PhD

Research Sponsored by University of California, Davis

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Individuals with idiopathic Parkinson's Disease who previously underwent implantation with the Boston Scientific VerciseTM DBS system

Individuals who are 18 years and older

Must not have

Individuals unable to provide consent and/or lack capacity to consent

Individuals diagnosed with any cognitive or physical impairments that would limit their ability to participate in the cognitive testing

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, hour 24, week 1, month 1, month 2, month 4, and month 5

Awards & highlights

No Placebo-Only Group

Summary

This trialwill test if stimulating the brain with low frequency in Parkinson's patients can improve their cognitive control.

Who is the study for?

This trial is for adults with advanced Parkinson's Disease who have had a specific type of deep brain stimulation (DBS) surgery using the Boston Scientific VerciseTM system. They must be able to consent, participate in cognitive tests, and not have severe cognitive or physical impairments.

What is being tested?

The study is testing low frequency stimulation of the ventral STN alongside standard high frequency stimulation of the dorsal STN in patients with Parkinson's. It aims to see if this can improve cognition without worsening motor symptoms.

What are the potential side effects?

Potential side effects may include changes in mood or behavior, headache, dizziness, difficulty concentrating, and other neurological effects related to DBS adjustments.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have Parkinson's and received a Boston Scientific Vercise DBS implant.

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I am 18 years old or older.

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I have advanced Parkinson's and underwent DBS surgery targeting the STN for motor improvement.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I am unable to give consent for myself.

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I do not have cognitive or physical impairments that limit my participation in tests.

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I am not fluent in English.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, hour 24, week 1, month 1, month 2, month 4, and month 5

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, hour 24, week 1, month 1, month 2, month 4, and month 5

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, hour 24, week 1, month 1, month 2, month 4, and month 5 for reporting.