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Alpha-1 Adrenergic Receptor Antagonist

Sertraline alone at steady state for PTSD

Phase 1
Waitlist Available
Research Sponsored by Otsuka Pharmaceutical Development & Commercialization, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 21 days
Awards & highlights
No Placebo-Only Group

Summary

This trial is testing how well Prazosin and Propranolol can manage blood pressure in patients who are already taking Brexpiprazole or Sertraline. Prazosin helps by relaxing blood vessels, while Propranolol works by slowing down the heart. The goal is to see if these medications can help control blood pressure issues caused by the mental health treatments.

Eligible Conditions
  • PTSD

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~21 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 21 days for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Changes between the control and treatment periods on Day 19 vs. Day 1, Day 20 vs. Day 2, and Day 21 vs. Day 3, with prazosin or propanolol in the presence of brexpiprazole + sertraline or sertraline alone at steady state

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Active Control
Group I: Sertraline alone at steady stateActive Control2 Interventions
To assess the hemodynamic changes associated with the effects of a single dose of prazosin or propranolol in the presence of brexpiprazole + sertraline at steady state compared with a single dose of prazosin or propranolol in the presence of sertraline alone at steady state.
Group II: Sertraline + brexpiprazole at steady stateActive Control2 Interventions
To assess the hemodynamic changes associated with the effects of a single dose of prazosin or propranolol in the presence of brexpiprazole + sertraline at steady state compared with a single dose of prazosin or propranolol in the presence of sertraline alone at steady state.

Find a Location

Who is running the clinical trial?

Otsuka Pharmaceutical Development & Commercialization, Inc.Lead Sponsor
264 Previous Clinical Trials
170,045 Total Patients Enrolled
Iqvia Pty LtdIndustry Sponsor
116 Previous Clinical Trials
174,536 Total Patients Enrolled
~11 spots leftby Nov 2025
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