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Electrolyte Replenisher

Normal Saline for Postural Orthostatic Tachycardia Syndrome

Phase 1
Waitlist Available
Led By Marvin S. Medow, Ph.D.
Research Sponsored by New York Medical College
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 1 week
Awards & highlights
No Placebo-Only Group

Summary

This trial tests a special drink with water, sugar, and salt to help young ME/CFS patients who struggle with standing. The drink helps the body absorb water better, which can improve blood flow and reduce symptoms.

Eligible Conditions
  • Vasovagal Syncope
  • Chronic Fatigue Syndrome
  • Postural Orthostatic Tachycardia Syndrome

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~1 week
This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 week for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
To test whether 1 Liter volumes of intravenous or oral rehydration solution increase total blood volume and cardiac output, comparably improving the threshold for orthostatic intolerance

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Group I: Oral rehydration solutionExperimental Treatment1 Intervention
Subjects will receive 1 liter of intravenous normal saline over 1 hour and on an alternate day Subjects will drink ORS solution 1 liter total by mouth over 20 minutes.
Group II: Normal SalineExperimental Treatment1 Intervention
Subjects will receive 1 liter of intravenous normal saline over 1 hour and on an alternate day Subjects will drink ORS solution 1 liter total by mouth over 20 minutes.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Oral Rehydration Solution
2021
Completed Phase 3
~30
Normal Saline
2019
Completed Phase 4
~1770

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

New York Medical CollegeLead Sponsor
71 Previous Clinical Trials
6,109 Total Patients Enrolled
5 Trials studying Postural Orthostatic Tachycardia Syndrome
275 Patients Enrolled for Postural Orthostatic Tachycardia Syndrome
National Institutes of Health (NIH)NIH
2,810 Previous Clinical Trials
8,159,587 Total Patients Enrolled
7 Trials studying Postural Orthostatic Tachycardia Syndrome
549 Patients Enrolled for Postural Orthostatic Tachycardia Syndrome
National Institute of Neurological Disorders and Stroke (NINDS)NIH
1,373 Previous Clinical Trials
650,993 Total Patients Enrolled
4 Trials studying Postural Orthostatic Tachycardia Syndrome
364 Patients Enrolled for Postural Orthostatic Tachycardia Syndrome
~5 spots leftby Nov 2025
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