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PF-07081532 for Type 2 Diabetes

Phase 1
Waitlist Available
Research Sponsored by Pfizer
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
No Placebo-Only Group

Summary

This trial tests PF-07081532, a potential diabetes treatment, in people with kidney problems. Participants will take the medicine orally and stay in the clinic for a short period while researchers monitor how their bodies process it.

Eligible Conditions
  • Type 2 Diabetes
  • Kidney Failure

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Side effects data

From 2021 Phase 1 trial • 66 Patients • NCT04305587
14%
Diarrhoea
14%
Vaccination complication
14%
Decreased appetite
14%
Dyspepsia
14%
Dermatitis contact
100%
80%
60%
40%
20%
0%
Study treatment Arm
PF-07081532 10 mg Part A
Placebo Part A
PF-07081532 30 mg Part A
PF-07081532 60 mg Part A
PF-07081532 120 mg Part A
Placebo Part B
PF-07081532 180 mg Part B
Placebo Part C
PF-07081532 180 mg Part C

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

4Treatment groups
Experimental Treatment
Group I: Group 4Experimental Treatment1 Intervention
Participants with severe renal impairment will receive a single 20 mg dose of PF 07081532, administered orally
Group II: Group 3Experimental Treatment1 Intervention
Participants with moderate renal impairment will receive a single 20 mg dose of PF 07081532, administered orally
Group III: Group 2Experimental Treatment1 Intervention
Participants with mild renal impairment will receive a single 20 mg dose of PF 07081532, administered orally
Group IV: Group 1Experimental Treatment1 Intervention
Participants without renal impairment will receive a single 20 mg dose of PF 07081532, administered orally
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
PF-07081532
2022
Completed Phase 1
~170

Find a Location

Who is running the clinical trial?

PfizerLead Sponsor
4,649 Previous Clinical Trials
17,744,358 Total Patients Enrolled
Pfizer CT.gov Call CenterStudy DirectorPfizer
3,536 Previous Clinical Trials
14,915,546 Total Patients Enrolled
~6 spots leftby Nov 2025
Unbiased ResultsWe believe in providing patients with all the options.
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