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Anti-estrogen

Anti-Estrogen Medication for Breast Cancer (MAPPER Trial)

Phase 2
Recruiting
Led By Lubna N Chaudhary, MD
Research Sponsored by Medical College of Wisconsin
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up time of surgery
Awards & highlights
No Placebo-Only Group

Summary

"This trial is testing a new approach where patients will start taking anti-estrogen medication before surgery for 4-12 weeks to see its effects."

Who is the study for?
This trial is for individuals with hormone receptor-positive, HER2-negative breast cancer. Participants will receive standard anti-estrogen treatment before surgery for about 4 to 12 weeks. Specific eligibility details are not provided.
What is being tested?
The study tests how effective aromatase inhibitors or tamoxifen are when given as a short-term neoadjuvant (pre-surgery) endocrine treatment in patients with certain types of breast cancer.
What are the potential side effects?
Potential side effects may include hot flashes, joint pain, fatigue, mood swings, and changes in menstrual flow for premenopausal women from aromatase inhibitors or tamoxifen.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~time of surgery
This trial's timeline: 3 weeks for screening, Varies for treatment, and time of surgery for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change from baseline in the number of subjects with increased HER-1 receptor tyrosine kinases protein expression in tumors.
Change from baseline in the number of subjects with increased HER-2 receptor tyrosine kinases protein expression in tumors.
Change from baseline in the number of subjects with increased HER-3 receptor tyrosine kinases protein expression in tumors.
+1 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Standard-of-care Endocrine therapyExperimental Treatment1 Intervention
Once enrolled, patients would be treated with the current standard-of-care endocrine therapy.

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Who is running the clinical trial?

Medical College of WisconsinLead Sponsor
628 Previous Clinical Trials
1,179,776 Total Patients Enrolled
14 Trials studying Breast Cancer
409,373 Patients Enrolled for Breast Cancer
Lubna N Chaudhary, MDPrincipal InvestigatorMedical College of Wisconsin
~67 spots leftby Dec 2028
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