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CAR T-cell Therapy

CAR T cells for Non-Hodgkin's Lymphoma

Phase 1 & 2
Waitlist Available
Led By Jun Zhu, MD
Research Sponsored by Peking University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 years.
Awards & highlights

Summary

Currently, a majority of lymphomas cannot be cured by standard chemo-radiotherapy. Cluster of differentiation antigen 30 (CD30) is expressed in many lymphoma subtypes, such as Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL). CD30 represents a very attractive target for chimeric antigen receptor (CAR)-based immune cell therapy. This study will evaluate a novel 4th generation CD30 CAR engineered with a self-withdrawal mechanism (FKBP-iCasp9) for both efficacy and safety evaluation in lymphoma patients.

Eligible Conditions
  • Non-Hodgkin's Lymphoma

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 years.
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 years. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Number of patients with adverse events.
Secondary study objectives
Response rates to the 4th generation CAR T cells.
Survival time of Anti-CD30 CAR T cells in vivo.
Survival time of the patients.

Trial Design

1Treatment groups
Experimental Treatment
Group I: CAR T cellsExperimental Treatment1 Intervention
Autologous 4th generation anti-CD30 CAR T cells

Find a Location

Who is running the clinical trial?

Peking UniversityLead Sponsor
450 Previous Clinical Trials
1,058,143 Total Patients Enrolled
University of FloridaOTHER
1,380 Previous Clinical Trials
762,375 Total Patients Enrolled
Jun Zhu, MDPrincipal InvestigatorPeking University Cancer Hospital & Institute
12 Previous Clinical Trials
823 Total Patients Enrolled
~2 spots leftby Sep 2025
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