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vadadustat for Coronavirus

Phase 2
Waitlist Available
Led By Bentley J. Bobrow, MD
Research Sponsored by The University of Texas Health Science Center, Houston
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day 14
Awards & highlights

Summary

This trial is testing vadadustat, a medication that may help prevent or treat severe lung problems in hospitalized COVID-19 patients. The drug works by helping the body handle low oxygen levels better. The goal is to see if it can reduce the risk or severity of acute respiratory distress syndrome (ARDS).

Eligible Conditions
  • Coronavirus
  • Acute Respiratory Distress Syndrome

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day 14
This trial's timeline: 3 weeks for screening, Varies for treatment, and day 14 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Number of participants who are classified 8 (dead), 7 (hospitalized, on invasive mechanical ventilation or ECMO), or 6 (hospitalized, on non-invasive ventilation or high flow oxygen devices) on the NIAID ordinal scale
Secondary study objectives
Number of participants with a total score of 0 on the Modified Sequential Organ Failure Assessment (MSOFA) scale
Other study objectives
Number of participants with hypotension
Score on the Modified Sequential Organ Failure Assessment (MSOFA) scale

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: vadadustatExperimental Treatment1 Intervention
Group II: placeboPlacebo Group1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
vadadustat
2018
Completed Phase 2
~550

Find a Location

Who is running the clinical trial?

Akebia Therapeutics Inc.UNKNOWN
1 Previous Clinical Trials
214 Total Patients Enrolled
United States Department of DefenseFED
891 Previous Clinical Trials
332,029 Total Patients Enrolled
The University of Texas Health Science Center, HoustonLead Sponsor
934 Previous Clinical Trials
333,359 Total Patients Enrolled
~90 spots leftby Sep 2025
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