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Sphingosine 1-phosphate receptor modulator

Etrasimod for Alopecia Areata

Phase 2
Waitlist Available
Research Sponsored by Pfizer
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up ole period: from first dosing date in ole up to last dosing date + 4 weeks + 3 days (maximum up to 33 weeks)
Awards & highlights

Summary

This trial is testing the safety and effectiveness of etrasimod, a medication taken alone, in people with significant hair loss due to alopecia areata. The drug works by adjusting the immune system to help reduce hair loss.

Eligible Conditions
  • Alopecia Areata

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~db treatment period: from first dosing date in db up to (before the first dosing date in ole) or (last dosing date + 4 weeks + 3 days), whichever is earlier (maximum up to 29 weeks)
This trial's timeline: 3 weeks for screening, Varies for treatment, and db treatment period: from first dosing date in db up to (before the first dosing date in ole) or (last dosing date + 4 weeks + 3 days), whichever is earlier (maximum up to 29 weeks) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Percent Change From Baseline in Severity of Alopecia Tool I (SALT I) at Week 24: DB Treatment Period
Secondary study objectives
Change From Baseline in SALT I at Week 24: DB Treatment Period
Percentage of Participants Who Achieved Greater Than or Equal to (>=) 30%, >= 50% and >=75% Improvement From Baseline in SALT I at Week 24: DB Treatment Period
Other study objectives
Number of Participants With Adverse Events (AE): DB Treatment Period
Number of Participants With Adverse Events: OLE Period

Side effects data

From 2022 Phase 3 trial • 42 Patients • NCT04706793
14%
Headache
11%
Malaise
11%
Pyrexia
7%
Colitis ulcerative
7%
Vaccination site pain
4%
Back pain
4%
COVID-19
4%
Contusion
100%
80%
60%
40%
20%
0%
Study treatment Arm
Placebo Comparator: Placebo
Experimental: Etrasimod 2 mg

Trial Design

3Treatment groups
Experimental Treatment
Placebo Group
Group I: Etrasimod 3 mgExperimental Treatment1 Intervention
Group II: Etrasimod 2 mgExperimental Treatment1 Intervention
Group III: PlaceboPlacebo Group1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Etrasimod
2020
Completed Phase 3
~1580

Find a Location

Who is running the clinical trial?

PfizerLead Sponsor
4,625 Previous Clinical Trials
14,284,114 Total Patients Enrolled
14 Trials studying Alopecia Areata
86,404 Patients Enrolled for Alopecia Areata
Arena is a wholly owned subsidiary of PfizerIndustry Sponsor
10 Previous Clinical Trials
2,430 Total Patients Enrolled
Arena PharmaceuticalsLead Sponsor
28 Previous Clinical Trials
5,661 Total Patients Enrolled
~16 spots leftby Sep 2025
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