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Radiation Therapy

Robotic Radiosurgery for Brain Metastasis (TRICK Trial)

Phase 3
Waitlist Available
Led By Timothy Whelan, MD FRCPC
Research Sponsored by Hamilton Health Sciences Corporation
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
* 1-3 brain metastases from a confirmed primary extra-cranial site
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up one year
Awards & highlights
Pivotal Trial
No Placebo-Only Group

Summary

Radiosurgery is precisely delivered high dose radiation. It can be performed using multiple cobalt sources, a modified traditional gantry-based linear accelerator or a robotic linear accelerator. The treatment of brain metastases represents the most common indication for radiosurgery while new indications for this technology are continually being discovered. With the increasing importance of radiosurgery and the resource implications for radiotherapy programs the investigators have proposed the first direct technological comparison of robotic to linear accelerator radiosurgery for brain metastases.

Eligible Conditions
  • Brain Metastasis

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~one year
This trial's timeline: 3 weeks for screening, Varies for treatment, and one year for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Radiosurgery planning and delivery time
Secondary study objectives
Acute Toxicity
Dosimetry
Late Toxicity
+3 more

Awards & Highlights

Pivotal Trial
The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Robotic RadiosurgeryExperimental Treatment1 Intervention
Single fraction radiosurgery will be prescribed using a robotic linear accelerator
Group II: Fixed Gantry RadiosurgeryActive Control1 Intervention
Single fraction radiosurgery will be prescribed using a Fixed Gantry Linear Accelerator

Find a Location

Who is running the clinical trial?

Ontario Clinical Oncology Group (OCOG)OTHER
64 Previous Clinical Trials
42,027 Total Patients Enrolled
Juravinski Cancer Centre FoundationOTHER
12 Previous Clinical Trials
1,893 Total Patients Enrolled
Hamilton Health Sciences CorporationLead Sponsor
377 Previous Clinical Trials
340,340 Total Patients Enrolled
~4 spots leftby Nov 2025
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