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RIC once per day for Vascular Cognitive Impairment (TRIC-VCI Trial)

Phase 2
Waitlist Available
Led By Eric Smith, MD
Research Sponsored by University of Calgary
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 30 days and 90 days
Awards & highlights

Summary

This trial will test whether RIC is a tolerable and effective treatment for patients with cognitive impairment due to cerebral small vessel disease.

Eligible Conditions
  • Vascular Cognitive Impairment
  • Cerebral Small Vessel Disease
  • Vascular Dementia

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~30 days and 90 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 30 days and 90 days for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Adherence
Secondary study objectives
Arm deep venous thrombosis
Discontinuation
Global cognition
+8 more

Trial Design

2Treatment groups
Active Control
Group I: RIC once per dayActive Control1 Intervention
RIC performed once a day on one arm. Each RIC session will consist of 4 cycles of unilateral or simultaneous bilateral upper arm ischemia for 5 minutes followed by reperfusion for another 5 minutes. The procedure will be performed by using an electric auto-control device with cuffs that inflate to a pressure of 200 mmHg during the ischemic period.
Group II: RIC twice per dayActive Control1 Intervention
RIC performed twice a day on one arm, approximately 12 hours apart. Each RIC session will consist of 4 cycles of unilateral or simultaneous bilateral upper arm ischemia for 5 minutes followed by reperfusion for another 5 minutes. The procedure will be performed by using an electric auto-control device with cuffs that inflate to a pressure of 200 mmHg during the ischemic period.

Find a Location

Who is running the clinical trial?

Canadian Institutes of Health Research (CIHR)OTHER_GOV
1,373 Previous Clinical Trials
26,519,218 Total Patients Enrolled
Canadian Consortium on Neurodegeneration in AgingOTHER
3 Previous Clinical Trials
3,050 Total Patients Enrolled
University of CalgaryLead Sponsor
805 Previous Clinical Trials
884,008 Total Patients Enrolled
1 Trials studying Vascular Cognitive Impairment
24 Patients Enrolled for Vascular Cognitive Impairment
~4 spots leftby Sep 2025
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