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minocycline hydrochloride for Anxiety Disorders
Phase 2
Waitlist Available
Led By Maryam Lustberg, MD
Research Sponsored by Ohio State University Comprehensive Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to 6 months
Awards & highlights
Summary
This trial studies if minocycline hydrochloride can help reduce depression and anxiety caused by chemotherapy in stage I-III breast cancer patients.
Eligible Conditions
- Anxiety Disorders
- Depression
- Breast Cancer
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline to 6 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to 6 months
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Changes in Center for Epidemiological Studies Depression Scale (CES-D) scores
Changes in the State Trait Anxiety Index (STAI) scores
Secondary study objectives
Changes in Hamilton Anxiety Rating Scale scores
Changes in Hamilton Rating Scale for Depression scores
Changes in inflammatory blood markers
+1 moreSide effects data
From 2017 Phase 2 trial • 22 Patients • NCT0174604320%
Peripheral Neuropathy
100%
80%
60%
40%
20%
0%
Study treatment Arm
Placebo
Armodafinil+Minocycline
Minocycline
Armodafinil
Trial Design
2Treatment groups
Experimental Treatment
Placebo Group
Group I: Arm I (minocycline hydrochloride)Experimental Treatment3 Interventions
Beginning 1 week prior to chemotherapy, patients receive minocycline hydrochloride orally PO BID for 9 weeks. Laboratory biomarker analysis will also be obtained weekly on protocol. Questionnaire administration weekly.
Group II: Arm II (placebo)Placebo Group3 Interventions
Beginning 1 week prior to chemotherapy, patients receive placebo PO BID for 9 weeks. Laboratory biomarker analysis will also be obtained weekly on protocol. Questionnaire administration weekly.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Minocycline
FDA approved
Find a Location
Who is running the clinical trial?
Ohio State University Comprehensive Cancer CenterLead Sponsor
334 Previous Clinical Trials
291,547 Total Patients Enrolled
3 Trials studying Anxiety Disorders
78 Patients Enrolled for Anxiety Disorders
Maryam Lustberg, MDPrincipal InvestigatorOhio State University Comprehensive Cancer Center
4 Previous Clinical Trials
294 Total Patients Enrolled
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