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Flavonoid

Fisetin for Chronic Kidney Disease

Phase 2
Waitlist Available
Led By LaTonya J Hickson, MD
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 months
Awards & highlights

Summary

This trial is testing fisetin, a natural substance from fruits and vegetables, to see if it can help people with advanced chronic kidney disease, especially those with diabetic kidney disease. Fisetin might reduce inflammation and improve cell function, potentially enhancing kidney health and physical strength.

Eligible Conditions
  • Chronic Kidney Disease
  • Diabetic Kidney Disease
  • Diabetes

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change in inflammatory markers including C-reactive protein
Effect on Mesenchymal stem cell function including cell migration
Secondary study objectives
Effect on measures of Frailty including Fried Criteria
Kidney function including estimated glomerular filtration rate
Kidney function including urine protein excretion rate
+1 more

Side effects data

From 2023 Phase 2 trial • 74 Patients • NCT04313634
10%
Pain in extremity
3%
Vertigo
3%
Menorrhagia
100%
80%
60%
40%
20%
0%
Study treatment Arm
Untreated Control Group
Dasatinib Plus Quercetin Treatment Goup
Fisetin Treatment Group

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: TreatmentExperimental Treatment1 Intervention
Fisetin 20 mg/kg/day, orally for 2 consecutive days
Group II: PlaceboPlacebo Group1 Intervention
Placebo capsules orally for 2 consecutive days
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Fisetin
2016
Completed Phase 2
~250

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,298 Previous Clinical Trials
3,958,415 Total Patients Enrolled
LaTonya J Hickson, MDPrincipal InvestigatorMayo Clinic
2 Previous Clinical Trials
32 Total Patients Enrolled
~4 spots leftby Dec 2025
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