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Propranolol Hydrochloride for Trauma and Stressor Related Disorders

Phase 2
Waitlist Available
Led By Alain Brunet, PhD.
Research Sponsored by Douglas Mental Health University Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up the weighted average of the questionnaire responses will be calculated over a 12 month period
Awards & highlights
Approved for 5 Other Conditions
All Individual Drugs Already Approved

Summary

This trial will explore whether reactivating a trauma memory while under the influence of propranolol will help relieve symptoms of trauma-related disorders more effectively than current treatments.

Eligible Conditions
  • Trauma and Stressor Related Disorders
  • Rivastigmine Side Effects
  • PTSD
  • Acute Stress Disorder
  • Adjustment Disorder

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~the weighted average of the questionnaire responses will be calculated over a 12 month period
This trial's timeline: 3 weeks for screening, Varies for treatment, and the weighted average of the questionnaire responses will be calculated over a 12 month period for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
EuroQol five dimensions questionnaire with five-level scale
Secondary study objectives
Hopkins Symptom Checklist - 25 (HSCL - 25).
Operational Police Stress Questionnaire (PSQ-OP)
Post-traumatic Checklist for the Diagnostic and Statistical Manual for Mental Disorders - 5th edition (PCL-5)
Other study objectives
Attention subtest of the Paced Auditory Serial Addition Test (PASAT)
Coding subtest of the Wechsler Adult Intelligence Scale-IV
Color-Word Interference Test of the Delis-Kaplan Executive Function System
+7 more

Awards & Highlights

Approved for 5 Other Conditions
This treatment demonstrated efficacy for 5 other conditions.
All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Propranolol HydrochlorideExperimental Treatment1 Intervention
1mg / kg of propranolol hydrochloride administered as a capsule 60 minutes prior to memory reactivation
Group II: PlaceboPlacebo Group1 Intervention
Placebo manufactured as a capsule to mimic 1mg/kg of propranolol hydrochloride administered 60 minutes prior to memory reactivation
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Propranolol
FDA approved

Find a Location

Who is running the clinical trial?

Douglas Mental Health University InstituteLead Sponsor
29 Previous Clinical Trials
2,684 Total Patients Enrolled
2 Trials studying Trauma and Stressor Related Disorders
234 Patients Enrolled for Trauma and Stressor Related Disorders
Institut de Recherche Robert-Sauvé en Santé et en Sécurité du TravailOTHER
3 Previous Clinical Trials
158 Total Patients Enrolled
Alain Brunet, PhD.Principal InvestigatorDouglas Mental Health University Institute
~7 spots leftby Nov 2025
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