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DNA Plasmid Therapy

30 mg dose of JVS-100 for Heart Failure (STOP-HF Trial)

Phase 2
Waitlist Available
Research Sponsored by Juventas Therapeutics, Inc.
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 months

Summary

This trial tests the safety and effectiveness of JVS-100 in patients with heart failure caused by poor blood supply to the heart. Participants will receive either a low dose or high dose and will be monitored over time to see if their heart function improves.

Eligible Conditions
  • Heart Failure

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Impact of JVS-100 injection on Quality of Life at 4 month follow-up
Impact of JVS-100 injection on Six Minute Walk Distance (6MWD) at 4 month follow-up
Secondary study objectives
Impact of JVS-100 Injection on LVEF
Impact of JVS-100 Injection on Major Adverse Cardiac Events
Impact of JVS-100 Injection on NYHA class
+4 more

Trial Design

3Treatment groups
Experimental Treatment
Placebo Group
Group I: 30 mg dose of JVS-100Experimental Treatment1 Intervention
30 mg dose of JVS-100
Group II: 15 mg dose of JVS-100Experimental Treatment1 Intervention
15 mg dose of JVS-100
Group III: PlaceboPlacebo Group1 Intervention

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Who is running the clinical trial?

Juventas Therapeutics, Inc.Lead Sponsor
5 Previous Clinical Trials
422 Total Patients Enrolled
3 Trials studying Heart Failure
254 Patients Enrolled for Heart Failure
~7 spots leftby Nov 2025
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