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Rose Geranium in Sesame Oil Nasal Spray for Nasal Vestibulitis

Phase 3
Waitlist Available
Led By Charles L Loprinzi
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 2 weeks after initiating the nasal spray
Awards & highlights

Summary

This trial is testing a nasal spray made from rose geranium and sesame oil on cancer patients undergoing chemotherapy. These patients often have nasal vestibulitis, which causes dryness and sores in the nose. The spray is believed to help by reducing inflammation and soothing the nasal passages. Rose geranium essential oil has been studied for its anti-inflammatory properties, and sesame oil has been shown to increase ciliary beat frequency in nasal mucosa.

Eligible Conditions
  • Nasal Vestibulitis
  • Cancer
  • Blood Cancers

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at 2 weeks after initiating the nasal spray
This trial's timeline: 3 weeks for screening, Varies for treatment, and at 2 weeks after initiating the nasal spray for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Response
Secondary study objectives
Incidence of adverse events (AEs)
Palliative Care
Severity of most prominent nasal symptom indicated at baseline

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Arm A (rose geranium in sesame oil nasal spray)Experimental Treatment2 Interventions
Patients instill rose geranium in sesame oil nasal spray, 1 spray in each nostril BID on days 1-14 in the absence of unacceptable toxicity.
Group II: Arm B (isotonic nasal saline)Placebo Group2 Interventions
Patients instill isotonic nasal saline, 1 spray in each nostril BID on days 1-14 in the absence of unacceptable toxicity. After 2 weeks, patients may instill rose geranium in sesame oil nasal spray as in Arm A for an additional 2 weeks in the absence of unacceptable toxicity.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Rose Geranium in Sesame Oil Nasal Spray
2020
Completed Phase 3
~60

Find a Location

Who is running the clinical trial?

Mayo ClinicLead Sponsor
3,298 Previous Clinical Trials
3,958,386 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,842 Previous Clinical Trials
41,002,941 Total Patients Enrolled
Charles L LoprinziPrincipal InvestigatorMayo Clinic in Rochester
3 Previous Clinical Trials
4 Total Patients Enrolled
~12 spots leftby Sep 2025
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