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Celecoxib for Obsessive-Compulsive Disorder (ACE-OCD Trial)

Phase 2
Recruiting
Led By S. Evelyn Stewart, MD
Research Sponsored by University of British Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 weeks, 12 weeks
Awards & highlights

Summary

This trial will compare the effectiveness of celecoxib to placebo as an additional treatment for children and youth with moderate to severe OCD.

Eligible Conditions
  • Obsessive-Compulsive Disorder
  • Mental Health Disorder

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 weeks, 12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 weeks, 12 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Children's Yale-Brown Obsessive-Compulsive Scale, 1st Edition (CY-BOCS-I)
Secondary study objectives
Mean Clinical Global Impression of Severity (CGI-S)
Mean Clinician Global Impression of Improvement (CGI-I)
Therapeutic procedure
+2 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: CelecoxibExperimental Treatment1 Intervention
Celecoxib 50 mg orally twice daily (if weight 10-25 kg) or 100 mg orally twice daily (if weight \> 25 kg) for 12 weeks. Used as adjunct to treatment-as-usual.
Group II: Placebo (microcrystalline cellulose)Placebo Group1 Intervention
Placebo capsules identical to celecoxib. One capsule orally twice daily for 12 weeks. Used as adjunct to treatment-as-usual.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Celecoxib
FDA approved

Find a Location

Who is running the clinical trial?

University of British ColumbiaLead Sponsor
1,451 Previous Clinical Trials
2,483,110 Total Patients Enrolled
6 Trials studying Obsessive-Compulsive Disorder
753 Patients Enrolled for Obsessive-Compulsive Disorder
BC Children's Hospital Research InstituteOTHER
12 Previous Clinical Trials
2,257 Total Patients Enrolled
Obsessive Compulsive FoundationOTHER
6 Previous Clinical Trials
173 Total Patients Enrolled
6 Trials studying Obsessive-Compulsive Disorder
173 Patients Enrolled for Obsessive-Compulsive Disorder
~19 spots leftby Sep 2025
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