Low-Dose Radiotherapy for COVID-19 Pneumonia (PREVENT Trial)

Phase 2

Waitlist Available

Led By Arnab Chakravarti, MD

Research Sponsored by Ohio State University Comprehensive Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Laboratory-confirmed diagnosis of SARS-CoV-2 pneumonia

Fever > 102 degrees Fahrenheit during index admission

Timeline

Screening 3 weeks

Treatment Varies

Follow Up the discharge of the last patient enrolled is estimated to be about 2 years.

Awards & highlights

No Placebo-Only Group

Summary

This trial is testing whether low doses of radiation can help treat pneumonia caused by the COVID-19 virus.

Who is the study for?

This trial is for hospitalized COVID-19 patients with confirmed pneumonia, experiencing symptoms like fever and cough for less than 9 days. They must have a high respiratory rate or need oxygen to maintain blood oxygen levels. Participants should be able to lie on the treatment couch and consent to the study.

What is being tested?

The trial tests if low-dose radiation therapy (35 cGy) can reduce lung inflammation in COVID-19 pneumonia, potentially decreasing ventilator reliance. It's compared against a higher dose (100 cGy). The x-ray beams target the lungs in a single session.

What are the potential side effects?

Historically, this type of low-dose chest radiation was effective without side effects but was replaced by cheaper treatments. Side effects are not detailed here but may include typical reactions to radiation.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have been diagnosed with COVID-19 pneumonia.

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I had a fever over 102°F during my hospital stay.

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I need oxygen therapy to keep my oxygen levels above 93%.

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I can lie down on a treatment table for radiation therapy.

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I have had symptoms like fever, cough, or difficulty breathing for less than 9 days.

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I am currently in the hospital due to COVID-19.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ the discharge of the last patient enrolled is estimated to be about 2 years.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~the discharge of the last patient enrolled is estimated to be about 2 years.

This trial's timeline: 3 weeks for screening, Varies for treatment, and the discharge of the last patient enrolled is estimated to be about 2 years. for reporting.