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Anti-metabolites

IXO regimen for Colorectal Cancer (IXOr Trial)

Phase 2
Waitlist Available
Led By Derek Jonker, MD
Research Sponsored by Ottawa Hospital Research Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up q6 months first 2 years and annually thereafter
Awards & highlights
No Placebo-Only Group

Summary

This is a prospective open label single-arm, single-institution phase II clinical trial to test the efficacy of neoadjuvant treatment with IXO (Irinotecan, Capecitabine \[Xeloda\], Oxaliplatin) followed by chemoradiotherapy and resection in patients with resectable non-metastatic primary rectal cancer of stage cT3-T4 N0-N2.

Eligible Conditions
  • Colorectal Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~q6 months first 2 years and annually thereafter
This trial's timeline: 3 weeks for screening, Varies for treatment, and q6 months first 2 years and annually thereafter for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Pathological complete response (pCR)
Secondary study objectives
Number of Participants with Adverse Events as a Measure of Safety and Tolerability
OS
Objective Response
+5 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups
Experimental Treatment
Group I: IXO regimenExperimental Treatment1 Intervention
single-group

Find a Location

Who is running the clinical trial?

Ottawa Hospital Research InstituteLead Sponsor
575 Previous Clinical Trials
3,094,866 Total Patients Enrolled
Ottawa Regional Cancer FoundationUNKNOWN
1 Previous Clinical Trials
23 Total Patients Enrolled
SanofiIndustry Sponsor
2,197 Previous Clinical Trials
4,034,841 Total Patients Enrolled
~1 spots leftby Nov 2025
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