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Vitamin

Vitamin C for Sepsis

Phase 2
Waitlist Available
Led By Michael D Sharpe, MD FRCPC
Research Sponsored by Lawson Health Research Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 28 days or discharge from intensive care unit
Awards & highlights

Summary

This study is designed to determine if Vitamin C administration to septic patients will result in an improvement in organ dysfunction which occurs during a septic illness. Hypothesis: 1. Vitamin C in sepsis will reduce the injury to organs 2. Vitamin C will reduce the length of time on a ventilator, length of stay in the intensive care unit and in hospital.

Eligible Conditions
  • Sepsis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~28 days or discharge from intensive care unit
This trial's timeline: 3 weeks for screening, Varies for treatment, and 28 days or discharge from intensive care unit for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Sequential organ function assessment score (SOFA)
Secondary study objectives
Biomarkers as a measure of coagulation, inflammation and oxidative stress.

Side effects data

From 2020 Phase 2 trial • 34 Patients • NCT01905150
22%
Nausea
11%
Insomnia
11%
Anorexia
11%
Anemia
11%
Fatigue
6%
Depression
6%
Diarrhea
6%
Pain
6%
Anxiety
100%
80%
60%
40%
20%
0%
Study treatment Arm
G-FLIP+VitaminC. When DP Occurred, Then G-FLIP-DM+Vitamin C.
G-FLIP Alone for 4 Weeks, Then G-FLIP+VitaminC. When DP Occurred, Then G-FLIP-DM+VitaminC

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Vitamin CExperimental Treatment1 Intervention
Intravenous Vitamin C will be administered (1 gram) every 8 hours for 28 days or discharge from intensive care unit
Group II: placeboPlacebo Group1 Intervention
placebo vehicle administered in same fashion as active treatment
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ascorbic acid
FDA approved

Find a Location

Who is running the clinical trial?

Lawson Health Research InstituteLead Sponsor
672 Previous Clinical Trials
414,491 Total Patients Enrolled
5 Trials studying Sepsis
1,750 Patients Enrolled for Sepsis
Michael D Sharpe, MD FRCPCPrincipal InvestigatorLondon Health Sciences Centre
2 Previous Clinical Trials
54 Total Patients Enrolled
~1 spots leftby Sep 2025
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