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Benzodiazepine

clonazepam conversion to clobazam (Onfi) for Epilepsy

Phase 4
Waitlist Available
Led By Steve Chung, MD
Research Sponsored by St. Joseph's Hospital and Medical Center, Phoenix
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up weeks 6 - 52 after medication conversion
Awards & highlights

Summary

This trial tests if clobazam (Onfi) is safe and effective for patients with difficult-to-treat epilepsy when it replaces clonazepam. The study aims to find the best dose, speed of conversion, and whether it improves seizure control and tolerability. Clobazam has been used internationally for many years as a safe and well-tolerated additional treatment for various types of epilepsy, including difficult-to-treat epilepsy.

Eligible Conditions
  • Epilepsy

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~weeks 6 - 52 after medication conversion
This trial's timeline: 3 weeks for screening, Varies for treatment, and weeks 6 - 52 after medication conversion for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Efficacy
Secondary study objectives
Retention
Tolerability

Trial Design

1Treatment groups
Experimental Treatment
Group I: clonazepam conversion to clobazam (Onfi)Experimental Treatment5 Interventions
Subject's clonazepam will be converted to clobazam (Onfi). This is an open label study without placebo control.

Find a Location

Who is running the clinical trial?

St. Joseph's Hospital and Medical Center, PhoenixLead Sponsor
66 Previous Clinical Trials
17,238 Total Patients Enrolled
H. Lundbeck A/SIndustry Sponsor
329 Previous Clinical Trials
77,649 Total Patients Enrolled
3 Trials studying Epilepsy
221 Patients Enrolled for Epilepsy
Steve Chung, MDPrincipal InvestigatorBanner Health Systems
~2 spots leftby Sep 2025
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