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Antifibrinolytic Agent

Tranexamic acid for Panniculectomy

Phase 4
Waitlist Available
Led By Amir Behnam, MD
Research Sponsored by The Reading Hospital and Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
• Patients undergoing panniculectomy or abdominoplasty.
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 56 days post operatively.
Awards & highlights

Summary

This trial is testing if a medication can reduce bleeding in patients having excess abdominal skin removed. The medication helps blood to clot, which may lead to less bleeding during and after surgery. It has been widely used to reduce blood loss in various surgical procedures, including aesthetic plastic surgery, hip replacement, and gynecologic surgery.

Eligible Conditions
  • Panniculectomy
  • Tummy Tuck

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to eight weeks post-operatively
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to eight weeks post-operatively for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Participants With Post Operative Hematoma
Post Surgical Drain Output in CCs
Secondary study objectives
Number of Days Until Drain Removal
Number of Participants That Returned to the Operating Room

Side effects data

From 2012 Phase 4 trial • 100 Patients • NCT00740116
22%
Readmissions
14%
Postoperative infections
10%
Re-operations
4%
Thromboembolic events
100%
80%
60%
40%
20%
0%
Study treatment Arm
Placebo Group
Tranexamic Group

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Group 2Experimental Treatment1 Intervention
The solution of Tranexamic Acid (TXA) will be placed into a sterile bowl in the operating area and three lap sponges will be placed in the solution at the beginning of the procedure. Group 2 will undergo application of three (TXA) soaked lap sponges to the surgical site. The lap sponges will be removed after three minutes and measurements will be taken for the study.
Group II: Group 1Placebo Group1 Intervention
The solution of saline will be placed into a sterile bowl in the operating area and three lap sponges will be placed in the solution at the beginning of the procedure. Group 1 will undergo application of three normal saline soaked lap sponges to the surgical site. The lap sponges will be removed after three minutes and measurements will be taken for the study.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Tranexamic acid
FDA approved

Find a Location

Who is running the clinical trial?

The Reading Hospital and Medical CenterLead Sponsor
13 Previous Clinical Trials
1,527 Total Patients Enrolled
Amir Behnam, MDPrincipal InvestigatorReading Hospital
~2 spots leftby Sep 2025
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