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Loop Diuretic

Administration of furosemide for Kidney Failure

Phase 4
Waitlist Available
Led By Marc B Goldstein, MD
Research Sponsored by Unity Health Toronto
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Inclusion Criteria:all patients taking Furosemide -
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 weeks
Awards & highlights

Summary

This trial aims to determine if dialysis patients still benefit from taking Furosemide, a drug that helps remove extra salt and water from the body. By comparing urine samples before and after taking the drug, researchers will see if it helps control blood pressure and reduce heart risks. The results will guide doctors on whether to continue prescribing Furosemide to these patients. Furosemide is a diuretic commonly used to treat fluid retention and swelling caused by various medical conditions, including chronic kidney disease and heart failure.

Eligible Conditions
  • Kidney Failure

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
24 hour urine sodium and water excretion
Secondary study objectives
Interdialytic weight gain
Other study objectives
The patients' BP on and off the drug will be compared

Side effects data

From 2017 Phase 4 trial • 57 Patients • NCT01441245
27%
rehospitalization for all cardiovascular causes
20%
death
100%
80%
60%
40%
20%
0%
Study treatment Arm
cIV Group
iIV Group

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Administration of furosemideExperimental Treatment1 Intervention
The patient will receive furosemide 120 mgms daily
Group II: Withdrawal of FurosemideActive Control1 Intervention
The patient's Furosemide will be withdrawn

Find a Location

Who is running the clinical trial?

Unity Health TorontoLead Sponsor
554 Previous Clinical Trials
454,240 Total Patients Enrolled
1 Trials studying Kidney Failure
215 Patients Enrolled for Kidney Failure
Marc B Goldstein, MDPrincipal InvestigatorUnity Health Toronto
~5 spots leftby Sep 2025
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