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Local Anesthetic

Bupivacaine for Lidocaine

N/A
Waitlist Available
Led By Jillian A Macdonald, MD
Research Sponsored by Ottawa Hospital Research Institute
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2, 4, 6, 8, 12, 24, 36, and 72 hours
Awards & highlights
No Placebo-Only Group
Approved for 10 Other Conditions
All Individual Drugs Already Approved

Summary

Mohs surgery is a very effective option in removing non-melanoma skin cancers, as the tissue being removed is analyzed the same day. If there are remnants of cancer cells in the tissue removed, the Mohs surgeon will go back and remove further tissue and repair the surgical wound all within the same day. Unfortunately, postoperative pain is quite prevalent among patients requiring Mohs procedures, as up to 52% require an additional oral pain medication. Lidocaine is the most commonly used anesthetic used in Mohs given its rapid onset of action. However, the duration of lidocaine's effect is much shorter than bupivacaine, which may translate into increased postoperative pain. To date, there are no specific studies comparing bupivacaine alone, lidocaine alone or both in conjunction in Mohs procedures. The investigators predict bupivacaine alone and bupivacaine used in conjunction with lidocaine are more effective in managing pain during Mohs surgery than lidocaine alone. To test our hypothesis, the investigators plan to have 105 patients receive either lidocaine alone, bupivacaine alone, or lidocaine and bupivacaine in conjunction during their Mohs procedure. Pain will be evaluated at various time points throughout the surgery.

Eligible Conditions
  • Lidocaine
  • Anesthesia
  • Mohs Surgery
  • Bupivacaine

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2, 4, 6, 8, 12, 24, 36, and 72 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2, 4, 6, 8, 12, 24, 36, and 72 hours for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Wong-Baker FACES Pain Rating Scale
Secondary study objectives
Adverse Event
Post-Operative Bleeding
Post-Operative Infection

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Approved for 10 Other Conditions
This treatment demonstrated efficacy for 10 other conditions.
All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.

Trial Design

3Treatment groups
Active Control
Group I: BupivacaineActive Control1 Intervention
Bupivacaine 0.5% with epinephrine 1:200,000 Injected at the start of every Mohs excision stage
Group II: Lidocaine and BupivacaineActive Control1 Intervention
Buffered lidocaine 1% with epinephrine 1:200,000 and bupivacaine 0.5% with epinephrine 1:200,000 injected sequentially. Injected at the start of every Mohs excision stage
Group III: LidocaineActive Control1 Intervention
Buffered lidocaine 1% with epinephrine 1:200,000 Injected at the start of every Mohs excision stage

Find a Location

Who is running the clinical trial?

Richard J. MacKay Endowment FundUNKNOWN
Benefactor Life Members' Research GrantUNKNOWN
The Ottawa Hospital Division of DermatologyUNKNOWN
~17 spots leftby Nov 2025