Vitamin C for Acute Pain (Vicamed Trial)

N/A

Waitlist Available

Led By Raoul Daoust, MD MSc

Research Sponsored by Hopital du Sacre-Coeur de Montreal

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 90 days

Summary

"This trial aims to determine if vitamin C can reduce pain intensity in patients with acute musculoskeletal pain over a seven-day period following an emergency department visit. Participants will either receive vitamin C or a placebo

Who is the study for?

This trial is for adults over 18 who visited the emergency department with acute musculoskeletal pain, like a fracture or sprain, that's lasted less than 48 hours. They should have a pain level of at least 4 out of 10 and be prescribed NSAIDs without opioids. It's not suitable for those who can't safely take vitamin C or acetaminophen.

What is being tested?

The study tests if vitamin C can help reduce pain after an ED visit for acute musculoskeletal issues. Participants will either get vitamin C or a placebo twice daily for seven days, along with regular doses of acetaminophen. Naproxen is provided as backup if needed.

What are the potential side effects?

Vitamin C is generally safe but may cause minor side effects like stomach upset in some people. Acetaminophen could lead to liver damage when used in large amounts or long-term, and naproxen may cause gastrointestinal issues.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ seven days

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~seven days

This trial's timeline: 3 weeks for screening, Varies for treatment, and seven days for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Daily pain intensity

Secondary study objectives

Adverse events

NSAIDs consumption

New analgesic prescriptions

+6 more

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Acetaminophen and Vitamin C with Naproxen rescueExperimental Treatment1 Intervention

900 mg vitamin C taken orally twice a day Extended-release acetaminophen 650 mg two pills every eight hours regularly Naproxen 500 mg as a rescue medication

Group II: Acetaminophen and Placebo with Naproxen rescuePlacebo Group1 Intervention

Placebo taken orally twice a day Extended-release acetaminophen 650 mg two pills every eight hours regularly Naproxen 500 mg as a rescue medication

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