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Sympathetic Nervous System Analysis for Coronary Artery Dissection
N/A
Recruiting
Led By Marysia Tweet, MD, MS
Research Sponsored by Mayo Clinic
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
For SCAD patients: history of SCAD as confirmed by coronary angiography or cardiac computed tomography angiography
For controls: no cardiac disease history
Must not have
Known or suspected unstable cardiac condition within 4 weeks of the study
Active treatment with anticoagulation or dual antiplatelet therapy
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline
Awards & highlights
No Placebo-Only Group
Summary
This trial compares the stress response and artery health of people who have had a heart artery tear to those who haven't. Researchers will measure how well their body's stress system works and how healthy their arteries are.
Who is the study for?
This study is for individuals with a history of spontaneous coronary artery dissection (SCAD), confirmed by specific heart imaging tests, and healthy volunteers without any cardiac disease. Pregnant women, those with unstable heart conditions recently, or on certain blood thinners can't participate.
What is being tested?
The trial investigates the sympathetic nervous system's activity (our body's fight or flight response) and arterial health in SCAD patients compared to healthy people using non-invasive tests like echocardiograms and carotid ultrasounds.
What are the potential side effects?
Since this study uses non-invasive diagnostic tools rather than medications, side effects are minimal but may include discomfort from tight pressure during tonometry or temporary skin marks from elastography.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
My SCAD diagnosis was confirmed through specific heart imaging tests.
Select...
I have never had heart disease.
Exclusion Criteria
You may be eligible for the trial if you check “No” for criteria below:Select...
I have not had any heart problems in the last month.
Select...
I am currently on blood thinners or taking two types of medication to prevent blood clots.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ baseline
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Arterial stiffness
Arterial thickness
Baroreflex sensitivity
+1 moreAwards & Highlights
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Trial Design
2Treatment groups
Experimental Treatment
Group I: Spontaneous coronary artery dissection (SCAD) groupExperimental Treatment6 Interventions
Subject with a history of SCAD will undergo a series of diagnostic studies to assess neurovascular function.
Group II: Healthy Control GroupExperimental Treatment6 Interventions
Healthy subjects will undergo a series of diagnostic studies to assess neurovascular function.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Echocardiogram
2016
Completed Phase 2
~1910
Elastography
2011
N/A
~720
Research Highlights
Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
The most common treatments for Spontaneous Coronary Artery Dissection (SCAD) often involve managing the sympathetic nervous system and improving arterial health. Medications such as beta-blockers are used to reduce heart rate and blood pressure, thereby decreasing the stress on the arterial walls.
This is crucial for SCAD patients as it helps prevent further arterial damage and promotes healing. Additionally, lifestyle changes like smoking cessation and caffeine reduction are recommended to minimize sympathetic nervous system activation, which can exacerbate arterial stress and stiffness.
These treatments aim to stabilize the arterial structure and mechanics, reducing the risk of recurrent dissection and improving overall cardiovascular health.
No impairment of sympathetic neurotransmission in stunned myocardium.Reduction of sympathetic inotropic response after ischemia in dogs. Contributor to stunned myocardium.Endoscopic thoracic sympathectomy--its effect in the treatment of refractory angina pectoris.
No impairment of sympathetic neurotransmission in stunned myocardium.Reduction of sympathetic inotropic response after ischemia in dogs. Contributor to stunned myocardium.Endoscopic thoracic sympathectomy--its effect in the treatment of refractory angina pectoris.
Find a Location
Who is running the clinical trial?
Mayo ClinicLead Sponsor
3,333 Previous Clinical Trials
3,060,125 Total Patients Enrolled
National Heart, Lung, and Blood Institute (NHLBI)NIH
3,928 Previous Clinical Trials
47,765,123 Total Patients Enrolled
Marysia Tweet, MD, MSPrincipal InvestigatorMayo Clinic
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- My SCAD diagnosis was confirmed through specific heart imaging tests.I have not had any heart problems in the last month.I am currently on blood thinners or taking two types of medication to prevent blood clots.I have never had heart disease.
Research Study Groups:
This trial has the following groups:- Group 1: Spontaneous coronary artery dissection (SCAD) group
- Group 2: Healthy Control Group
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
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