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Bone-patellar tendon-bone (BPTB) for Anterior Cruciate Ligament Reconstruction

N/A

Recruiting

Led By Bryan Heiderscheit, PT, PhD

Research Sponsored by University of Wisconsin, Madison

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 2 weeks

Awards & highlights

No Placebo-Only Group

Summary

The goal of this observational study is to understand how diffusion tensor imaging (DTI) relates to other traditional measures and knee function. The main question it aims to answer is: Will regions of known patellar tendon pathology present with smaller DTI scalar parameters, shorter fiber length, and lower fiber density compared to the contralateral tendon and healthy regions in the ipsilateral tendon. Participants will: * undergo MRI and ultrasound imaging * perform knee function test * complete questionnaires

Eligible Conditions

Anterior Cruciate Ligament Reconstruction
Jumper's knee

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 2 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 2 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 2 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Compare DTI scalar parameters of known patellar tendon pathology to the healthy regions in the ipsilateral tendon

Compare scalar parameters of known patellar tendon pathology to the contralateral tendon

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Experimental Treatment

Group I: Patellar tendinopathy groupExperimental Treatment2 Interventions

This group will have patellar tendinopathy confirmed based on International Scientific Tendinopathy Symposium Consensus on Clinical Terminology (ICON) statement, which defines patellar tendinopathy as "persistent patellar tendon pain and loss of function related to mechanical loading." Ultrasound diagnosis must confirm alteration of tendon macrostructure.

Group II: Bone-patellar tendon-bone (BPTB)Experimental Treatment2 Interventions

This group will have patellar injury confirmed through self-reported surgical history and evidence of ipsilateral BPTB graft harvest on ultrasound.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Ultrasound (US)

2015

Completed Phase 4

~40

MRI

2009