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Behavioral Intervention

Intervention for Stroke (MITTXS Trial)

N/A
Waitlist Available
Led By Andre Lindsey, PhD
Research Sponsored by Nevada State University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Presents with language and motor speech impairments
Be older than 18 years old
Must not have
Uncorrected auditory or visual impairments
Not meeting the criteria of stroke
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline and one week following the end of treatment
Awards & highlights

Summary

This trial is looking at how music therapy and video feedback can help people who have trouble speaking due to a condition called nonfluent aphasia. Nonfluent aphasia makes it hard for people to

Who is the study for?
This trial is for English-speaking individuals who have had a stroke on the left side of their brain, resulting in language and speech difficulties. They must not have learning disabilities prior to the stroke, uncorrected hearing or vision issues, psychiatric disorders, or lack proof of their stroke diagnosis.
What is being tested?
The study investigates intensive melodic intonation therapy alongside video feedback performance review to help those with nonfluent aphasia and motor speech problems after a stroke. It aims to improve word retrieval and speech fluency.
What are the potential side effects?
Since this trial involves therapy sessions rather than medication, traditional side effects are not expected. Participants may experience fatigue or frustration during intensive therapy sessions.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have difficulty speaking or moving.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have hearing or vision problems that haven't been corrected.
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I have not had a stroke.
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I had a learning disability before my accident.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and one and four weeks following the end of treatment
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and one and four weeks following the end of treatment for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Intelligibility
Secondary study objectives
Apraxia Battery for Adults
Assessment of Intelligibility of Dysarthria Speech
Longer Connected Speech Assessment
+1 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: InterventionExperimental Treatment2 Interventions
20 sessions/4 weeks: Video Feedback: S1) Participant (P1) views recording of previous session with the clinician & judges whether the production is intelligible. S2) S1 & the clinician identifies changes in motor movements that are influencing performance. S3+S4) S1+S2 & given support from the clinician, P1 identifies techniques improving intelligibility & modifies behavior accordingly. MIT: Humming - Clinician introduces the target phrase by showing a visual cue, humming the phrase, then intoning (singing) the phrase while P1 taps left-hand. Unison intoning - Clinician and P1 intone (sing) & tap the target phrase together. Unison intoning with fading - Clinician & P1 begin to intone (sing) & tap the target phrase together. The clinician fades out, while P1 continues to sing the rest of the phrase accompanied by tapping. Immediate repetition response to probe question - Following P1's successful repetition, the clinician intones a question and P1 intones the target.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Melodic Intonation Therapy
2008
Completed Phase 3
~50

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Who is running the clinical trial?

Nevada State UniversityLead Sponsor
Andre Lindsey, PhDPrincipal InvestigatorNevada State University
~1 spots leftby Sep 2025
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