What side effects are associated with this type of intervention?

Common treatments for obesity include dietary interventions, such as low-fat and low-carbohydrate diets, and pharmacologic treatments like GLP-1 receptor agonists and combinations of phentermine and topiramate. Dietary interventions can lead to side effects such as constipation, headache, halitosis, muscle cramps, diarrhea, general weakness, and rash. Pharmacologic treatments may cause nausea, vomiting, diarrhea, and potential cardiovascular effects. While dairy products are being studied for their potential benefits in weight control and metabolic health, their side effects are generally minimal but can include lactose intolerance symptoms in sensitive individuals.

What prior FDA approvals exist?

The FDA has approved several drugs for the treatment of obesity, including combinations like phentermine-topiramate, which has shown significant weight loss in clinical trials. This combination therapy enhances weight loss by combining the effects of two drugs, similar to how nutrient combinations in dairy products might counteract negative effects. Other approved treatments include liraglutide and semaglutide, which are GLP-1 receptor agonists that help with weight management and have shown efficacy in reducing body weight. These treatments, while pharmacological, share a common goal with dietary interventions in managing obesity and improving metabolic health.

What other types of research exist?

Promising novel alternatives to dairy products for obesity patients include: 1) Plant-based milk alternatives (e.g., almond, soy, oat milk) which are often fortified with essential nutrients like calcium and vitamin D. 2) Fermented plant-based products (e.g., coconut yogurt, cashew cheese) that can support gut health. 3) Bioactive peptides derived from non-dairy sources, which can offer antimicrobial and hypotensive benefits similar to those found in milk-based peptides. These alternatives can provide essential nutrients, support metabolic health, and aid in weight management.

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Dairy Fat Content for Obesity Management

N/A

Recruiting

Led By Vicky Drapeau, PhD, RD

Research Sponsored by Laval University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

men and women between 18-55 years

absence of pregnancy, breastfeeding or menopause (no menstruation)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up week 0, week 9, week 24

Awards & highlights

No Placebo-Only Group

Summary

This trial is testing whether eating more full-fat or low-fat dairy products can help improve health in adults and children. The study focuses on people who are either normal weight or living with obesity. Researchers will look at how dairy affects appetite, food intake, blood sugar levels, body weight, cholesterol, and blood pressure.

Who is the study for?

This trial is for men and women aged 18-55 with a BMI of 30-40, not pregnant, breastfeeding or in menopause. It includes families with at least one obese parent and two children (8-16 years). Participants should have stable weight, no dairy allergies or lactose intolerance, and can have hypertension or blood sugar/lipid issues.

What is being tested?

The study compares the effects of full-fat versus low-fat dairy products on appetite, food intake, blood sugar control, body weight management, cholesterol levels, and blood pressure in both normal-weight and overweight individuals including adults and children.

What are the potential side effects?

While specific side effects are not listed for consuming full-fat or low-fat dairy products within the provided information about this trial; typically such dietary changes may cause digestive discomfort depending on individual tolerance to lactose and fat content.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am between 18 and 55 years old.

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I am not pregnant, breastfeeding, or in menopause.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ week 0, week 9, week 24

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~week 0, week 9, week 24

This trial's timeline: 3 weeks for screening, Varies for treatment, and week 0, week 9, week 24 for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Dairy consumption

Secondary study objectives

Anxiety symptoms

Binge Eating Tendencies

Body weight (kg)

+14 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups

Active Control

Group I: Low-fat dairy productsActive Control1 Intervention

Consumption of low-fat dairy products (4 servings/day with 2 servings/day coming from yogurt)

Group II: Full-fat dairy productsActive Control1 Intervention

Consumption of high-fat dairy products (4 servings/day with 2 servings/day coming from yogurt)

Group III: ControlActive Control1 Intervention

Will be recommended to choose low-fat dairy products and alternatives based on recommendations from the 2007 Canadian Food Guide (2 servings/day for adults and 3-4 servings/day for children)

0 / 2Eligibility criteria met

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.

Mechanism Of Action

Side Effect Profile

Prior Approvals

Other Research

Common treatments for obesity include dietary interventions, pharmacotherapy, and behavioral strategies. Dietary interventions often focus on reducing calorie intake and optimizing macronutrient composition, such as low-fat or low-carbohydrate diets, to promote weight loss and improve metabolic health. Pharmacotherapy aims to reduce appetite or increase metabolic rate through medications that act on central or peripheral pathways. Behavioral strategies involve lifestyle changes, including increased physical activity and psychological support, to sustain long-term weight loss. The study of dairy products, particularly their nutrient combinations and physical forms, is relevant as they may influence satiety, food intake, and metabolic parameters, potentially offering a dietary solution for improved weight management and metabolic health in obesity patients.

Pharmacotherapy of obesity: emerging drugs and targets.