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80% Sub-symptom threshold aerobic exercise for Post-Concussion Syndrome

N/A
Waitlist Available
Led By Kathryn Schneider, PT, PhD
Research Sponsored by Sport Injury Prevention Research Centre
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 0-8 weeks (or time of medical clearance if prior to 8 weeks)
Awards & highlights
No Placebo-Only Group

Summary

Although the vast majority of individuals sustaining a sport-related concussion (SRC) will receive medical clearance to return to sport within 7-10 days, approximately 30% of children and adolescents reporting to the emergency department will experience symptoms that last longer than a month. Research has demonstrated that exercise below the threshold that results in increases in symptoms, beyond those experienced at rest, (sub-symptom threshold aerobic exercise) may be beneficial in recovery. However, the optimal amount and intensity of aerobic exercise for an individual to experience the most beneficial outcomes is currently unknown. Unfortunately there are limited Randomized Controlled Trials (RCT's) evaluating the benefits of aerobic exercise in a youth population. The current evidence includes studies with relatively small sample sizes, unreliable measurements of physical activity (self-report), and inherent biases through inadequate blinding. There is a need to develop and validate evidence-informed interventions as a means of treatment for limiting time loss from sport, and school in adolescents who experience persistent symptoms of sports related concussion beyond 10 days.

Eligible Conditions
  • Post-Concussion Syndrome
  • Concussion
  • Aerobic Exercise
  • Traumatic Brain Injury
  • Rehabilitation

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~0-8 weeks (or time of medical clearance if prior to 8 weeks)
This trial's timeline: 3 weeks for screening, Varies for treatment, and 0-8 weeks (or time of medical clearance if prior to 8 weeks) for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Days to receive medical clearance to return to sport
Secondary study objectives
Activity (kcal/day)
Adherence to prescribed exercise
Cognitive activity
+4 more

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: 80% Sub-symptom threshold aerobic exerciseExperimental Treatment1 Intervention
The moderate intensity intervention group will exercise at 80% of the maximum symptom free heart rate identified by their most recent graded treadmill test. The target heart rate zone will be within of the heart rate at which they experienced an increase in symptoms. The participants will be instructed to follow a program of moderate intensity activity in the form of their choice, we will recommend the following: stationary cycling, brisk walking, light jogging or the use of any available cardiovascular exercise equipment where they can control and monitor their heart rate wearing both the Actigraph and Polar HR monitor provided.
Group II: 60% Sub-symptom aerobic exerciseActive Control1 Intervention
The light (conservative) intensity intervention group will exercise at 60% of the maximum symptom free heart rate identified by their most recent graded treadmill test. The target heart rate zone will be within of the heart rate at which they experienced an increase in symptoms. The low intensity group will perform their exercise program at their own discrepancy however we will advise either of the following activities: light walking, stationary cycling or the use of any available cardiovascular exercise equipment where they can control and monitor their heart rate while simultaneously wearing both the Actigraph and polar HR monitor.

Find a Location

Who is running the clinical trial?

Sport Injury Prevention Research CentreLead Sponsor
8 Previous Clinical Trials
4,228 Total Patients Enrolled
University of ManitobaOTHER
618 Previous Clinical Trials
206,573 Total Patients Enrolled
Kathryn Schneider, PT, PhDPrincipal InvestigatorSport Injury Prevention Research Centre
~17 spots leftby Nov 2025