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Children admitted to CHU de Quebec University Laval Hospital for Bronchiolitis (CareBEST Trial)

N/A
Recruiting
Led By Olivier Drouin, MD, MSc, MPH
Research Sponsored by St. Justine's Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 24 months
Awards & highlights

Summary

Low-value care is defined as the use of a health service, such as diagnostics and treatments, for which the harms or costs outweigh the benefits. In pediatrics, investigations or treatments can be unpleasant or traumatizing to the child, can prolong the time spent in hospital, and can create a cascade of further futile investigations and treatments. Several of the commonly used diagnostics and treatments in bronchiolitis are considered low-value, making it a great model to study low-value care in pediatrics. The purpose of CareBEST is to study the use of 6 low-value healthcare services in children aged 1 to 12 months hospitalized with bronchiolitis, their costs, and measure the variability in practice of these services. The main questions this study aims to answer are: 1. How frequently are 6 low-value care health services used in children hospitalized with bronchiolitis? These 6 low-value care health services are: 1) respiratory virus testing; 2) chest x-rays; 3) continuous pulse oximetry; 4) short-acting beta-agonists; 5) systemic corticosteroids; and 6) antibiotics. * Are there factors that predict the use of these services? * What are the costs of the use of these services? 2. How much variability is there between different patients, different doctors, and between hospitals in the use of these 6 low-value health services ? 3. Are differences in use of low-value health services associated with patient and family characteristics (like race and ethnicity, socioeconomic status, language), and do these contribute to disparities in care? Participants will have their infant's medical chart reviewed during their hospitalization. They will also have 2 short questionnaires to complete, once during their child's admission to the hospital, and one 30 days later to ask about whether their child required any additional medical care. This analysis will provide a better understanding of treatment of bronchiolitis in Canada and help in the development of effective interventions to reduce low-value care.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 months for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
The proportion of eligible patients receiving each of the six low-value health services
Secondary study objectives
Antiviral prescription
Cardiac arrest
Care received in the 30 days following discharge.
+18 more

Trial Design

18Treatment groups
Experimental Treatment
Group I: Children admitted to The Hospital for Sick KidsExperimental Treatment1 Intervention
Children aged \>28 days to \<12 months with an admission diagnosis of bronchiolitis, admitted to a general pediatric inpatient unit, not previously recruited for the study.
Group II: Children admitted to Stollery Children's HospitalExperimental Treatment1 Intervention
Children aged \>28 days to \<12 months with an admission diagnosis of bronchiolitis, admitted to a general pediatric inpatient unit, not previously recruited for the study.
Group III: Children admitted to Montreal Children's HospitalExperimental Treatment1 Intervention
Children aged \>28 days to \<12 months with an admission diagnosis of bronchiolitis, admitted to a general pediatric inpatient unit, not previously recruited for the study.
Group IV: Children admitted to McMaster Children's HospitalExperimental Treatment1 Intervention
Children aged \>28 days to \<12 months with an admission diagnosis of bronchiolitis, admitted to a general pediatric inpatient unit, not previously recruited for the study.
Group V: Children admitted to Lakeridge HealthExperimental Treatment1 Intervention
Children aged \>28 days to \<12 months with an admission diagnosis of bronchiolitis, admitted to a general pediatric inpatient unit, not previously recruited for the study.
Group VI: Children admitted to Kingston Health Sciences CentreExperimental Treatment1 Intervention
Children aged \>28 days to \<12 months with an admission diagnosis of bronchiolitis, admitted to a general pediatric inpatient unit, not previously recruited for the study.
Group VII: Children admitted to IWK Children's HospitalExperimental Treatment1 Intervention
Children aged \>28 days to \<12 months with an admission diagnosis of bronchiolitis, admitted to a general pediatric inpatient unit, not previously recruited for the study.
Group VIII: Children admitted to Hôpital St-JérômeExperimental Treatment1 Intervention
Children aged \>28 days to \<12 months with an admission diagnosis of bronchiolitis, admitted to a general pediatric inpatient unit, not previously recruited for the study.
Group IX: Children admitted to Hôpital Saint-EustacheExperimental Treatment1 Intervention
Children aged \>28 days to \<12 months with an admission diagnosis of bronchiolitis, admitted to a general pediatric inpatient unit, not previously recruited for the study.
Group X: Children admitted to Cité-de-la-SantéExperimental Treatment1 Intervention
Children aged \>28 days to \<12 months with an admission diagnosis of bronchiolitis, admitted to a general pediatric inpatient unit, not previously recruited for the study.
Group XI: Children admitted to Children's Hospital of Western OntarioExperimental Treatment1 Intervention
Children aged \>28 days to \<12 months with an admission diagnosis of bronchiolitis, admitted to a general pediatric inpatient unit, not previously recruited for the study.
Group XII: Children admitted to Children's Hospital of Eastern OntarioExperimental Treatment1 Intervention
Children aged \>28 days to \<12 months with an admission diagnosis of bronchiolitis, admitted to a general pediatric inpatient unit, not previously recruited for the study.
Group XIII: Children admitted to CHU de Quebec University Laval HospitalExperimental Treatment1 Intervention
Children aged \>28 days to \<12 months with an admission diagnosis of bronchiolitis, admitted to a general pediatric inpatient unit, not previously recruited for the study.
Group XIV: Children admitted to CHU Sainte-JustineExperimental Treatment1 Intervention
Children aged \>28 days to \<12 months with an admission diagnosis of bronchiolitis, admitted to a general pediatric inpatient unit, not previously recruited for the study.
Group XV: Children admitted to British Columbia Children's HospitalExperimental Treatment1 Intervention
Children aged \>28 days to \<12 months with an admission diagnosis of bronchiolitis, admitted to a general pediatric inpatient unit, not previously recruited for the study.
Group XVI: Children admitted to Alberta Children's HospitalExperimental Treatment1 Intervention
Children aged \>28 days to \<12 months with an admission diagnosis of bronchiolitis, admitted to a general pediatric inpatient unit, not previously recruited for the study.
Group XVII: Children Admitted to Trillium Health PartnersExperimental Treatment1 Intervention
Children aged \>28 days to \<12 months with an admission diagnosis of bronchiolitis, admitted to a general pediatric inpatient unit, not previously recruited for the study.
Group XVIII: Children Admitted to Hôpital Maisonneuve-RosemontExperimental Treatment1 Intervention
Children aged \>28 days to \<12 months with an admission diagnosis of bronchiolitis, admitted to a general pediatric inpatient unit, not previously recruited for the study.

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Who is running the clinical trial?

St. Justine's HospitalLead Sponsor
198 Previous Clinical Trials
81,240 Total Patients Enrolled
4 Trials studying Bronchiolitis
1,634 Patients Enrolled for Bronchiolitis
Maternal Infant Child and Youth Research NetworkUNKNOWN
The Hospital for Sick ChildrenOTHER
704 Previous Clinical Trials
6,953,877 Total Patients Enrolled
8 Trials studying Bronchiolitis
2,137 Patients Enrolled for Bronchiolitis
~2000 spots leftby May 2026