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Laser Modality

MOSES Laser System for Kidney Stones

N/A
Recruiting
Research Sponsored by Albany Medical College
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Large renal calculi burden of single or multiple stones with the sum of its longest diameters between 10-20 mm
Adults between the ages of 18-80
Must not have
Patients with a history of ipsilateral upper urinary tract reconstructive procedures on the side of the renal calculi
Patients with a history of prior radiotherapy of the abdomen or pelvis
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 2 hours
Awards & highlights
No Placebo-Only Group

Summary

This trial will test new technique to reduce stone size and time of surgery for patients with large kidney stones.

Who is the study for?
This trial is for adults aged 18-80 with large kidney stones (10-20 mm in total diameter) and a stone density of at least 1000 Hounsfield units. Suitable candidates can undergo flexible ureteroscopy. Pregnant individuals, those currently battling infections or cancer, patients with spinal cord injuries, neurogenic bladder, abnormal kidney anatomy, history of certain urinary tract procedures or strictures, prior abdominal/pelvic radiotherapy, or on non-stop anticoagulants are excluded.
What is being tested?
The study tests the MOSES laser system's effectiveness in reducing lasing time and energy during ureteroscopic removal of large dense kidney stones using different techniques: dusting them into fine particles, breaking them into fragments or combining both methods.
What are the potential side effects?
While not explicitly stated here, typical side effects from similar procedures may include discomfort during urination, blood in urine post-procedure due to tissue irritation by the laser treatment and potential infection risks.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have large kidney stones measuring in total 10-20 mm.
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I am between 18 and 80 years old.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
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I have had surgery on the same side as my kidney stones before.
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I have had radiation therapy in my abdomen or pelvis before.
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I have an unusual kidney shape, like a horseshoe kidney.
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I am currently receiving treatment for an infection or cancer.
Select...
I have had a spinal cord injury in the past.
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My kidney stones are either smaller than 10mm or larger than 20mm.
Select...
I need to take blood thinners regularly and cannot stop them for surgery.
Select...
I cannot have a tube placed in my ureter.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 hours for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Less Energy Transmission to Patient
Reduced OR time

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

3Treatment groups
Experimental Treatment
Group I: Flexible Ureteroscopy with HybridExperimental Treatment1 Intervention
Flexible ureteroscopy utilizing the Hybrid lasing technique which will use both sets of parameters.
Group II: Flexible Ureteroscopy with FragmentationExperimental Treatment1 Intervention
Flexible ureteroscopy utilizing the Fragmentation lasing technique. MOSES parameters will be set to 0.8-1 JULES and a frequency of 8-10 hertz
Group III: Flexible Ureteroscopy with DustingExperimental Treatment1 Intervention
Flexible ureteroscopy with the dusting lasing technique. MOSES parameters will be set to an energy of 0.3-0.4 Jules and a frequency of 50-80 hertz

Find a Location

Who is running the clinical trial?

Albany Medical CollegeLead Sponsor
94 Previous Clinical Trials
12,441 Total Patients Enrolled

Media Library

MOSES laser system (Laser Modality) Clinical Trial Eligibility Overview. Trial Name: NCT05869890 — N/A
Kidney Stones Research Study Groups: Flexible Ureteroscopy with Dusting, Flexible Ureteroscopy with Fragmentation, Flexible Ureteroscopy with Hybrid
Kidney Stones Clinical Trial 2023: MOSES laser system Highlights & Side Effects. Trial Name: NCT05869890 — N/A
MOSES laser system (Laser Modality) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05869890 — N/A
~10 spots leftby Feb 2025
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