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Behavioral Intervention

Cognitive Training for Cognitive Impairment

N/A

Waitlist Available

Led By Susanne M. Jaeggi, PhD

Research Sponsored by University of Wisconsin, Madison

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Must not have

History of seizures, focal brain lesion, or head injury with loss of consciousness in the past year

Plans to travel out of the area for more than 1 week during the intervention period

Timeline

Screening 3 weeks

Treatment Varies

Follow Up end of post-test (up to 60 days)

Awards & highlights

No Placebo-Only Group

Summary

This trial will involve 1600 people to test if cognitive training works. Participants will be split into different groups and will take part in the study for up to 15 hours over 4 to

Who is the study for?

This trial is for individuals experiencing cognitive impairment. It's designed to include a wide age range, so both older and younger adults can participate. The main requirement is the ability to perform visual and/or auditory tasks.

What is being tested?

The study tests how effective different types of cognitive training are on improving mental functions. Participants will be randomly assigned to groups that receive either one or two types of visual/auditory tasks over a period of 4-8 weeks.

What are the potential side effects?

Since this trial involves non-invasive cognitive tasks, there are minimal expected side effects. Participants may experience fatigue or mental strain from the exercises.

Eligibility Criteria

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have had seizures, a brain injury, or was unconscious due to a head injury in the last year.

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I plan to travel for more than a week during the study.

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I have a physical disability that makes it hard for me to participate in training.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ pre-test (baseline), post-test1 up to 30 days, (unmasked) post-test2 up to 60 days

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~pre-test (baseline), post-test1 up to 30 days, (unmasked) post-test2 up to 60 days

This trial's timeline: 3 weeks for screening, Varies for treatment, and pre-test (baseline), post-test1 up to 30 days, (unmasked) post-test2 up to 60 days for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Change in the difference between the proportion of hits minus false alarms for a given level of the N-back task

Change in the difference of response time and accuracy in switch trials minus non-switch trials in the Task Switching Task

Change in the difference of response time in (i) switch trials minus non-switch trials and (ii) congruent minus incongruent trials in the Flanker Task

+11 more

Secondary study objectives

Behavioral Inhibition/Activation System (BIS/BAS) Score

Big-5-Inventory 10-item version (BFI-10) Score

Brief Pittsburgh Sleep Quality Index (B-PSQI) Score

+10 more

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups

Active Control

Group I: Long Testing GroupActive Control2 Interventions

Participants will go through 2 assessment sessions over 2-3 days (75 minutes each), followed by 10 sessions of cognitive tasks over 2 weeks in-lab or at-home, 1 session of 75 minutes about 2 weeks later, another 10 sessions of cognitive tasks over 2 weeks in-lab or at-home, then 2 sessions (\~45 minutes) over 2-3 days about 2 weeks after this session, and finally another 2 sessions (\~45 minutes) 3 days to 2 weeks after that session. Unless otherwise specified, all the sessions will take place in the lab.

Group II: Short Testing GroupActive Control1 Intervention

Participants will go through 2 assessment sessions over 2-3 days (\~75 minutes each), followed by 1 session of 75 minutes about 2 weeks later, 2 further sessions (\~45 minutes) over 2-3 days about 2 weeks after this session, and finally another 2 sessions (\~45 minutes) 3 days to 2 weeks after that session. All the sessions will take place in the lab.

0 / 3Eligibility criteria met