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Aerobic Exercise During Chemotherapy for Colorectal Cancer (ACTION Trial)

N/A
Recruiting
Led By Justin C. Brown, Ph.D.
Research Sponsored by Pennington Biomedical Research Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12- or 24-weeks

Summary

This trial will measure how exercise affects cancer survivors' chemotherapy treatment and its effectiveness.

Who is the study for?
This trial is for adults over 18 with stage II or III colon cancer who've had surgery to remove it and are about to start chemo. They should exercise less than an hour a week, be able to walk 400 meters, understand English, and be ready to exercise as per a questionnaire.
What is being tested?
The study measures how different amounts of aerobic exercise affect the body's response to chemotherapy in colon cancer survivors compared to those doing just stretching exercises.
What are the potential side effects?
While not drug-related, potential side effects from aerobic exercise may include muscle soreness, fatigue, and increased risk of injury if not done properly.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12- or 24-weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12- or 24-weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Chemotherapy Relative Dose Intensity

Trial Design

5Treatment groups
Experimental Treatment
Placebo Group
Group I: 75 min/wk aerobic exerciseExperimental Treatment1 Intervention
Aerobic exercise at a dose of 75 minutes per week
Group II: 300 min/wk aerobic exerciseExperimental Treatment1 Intervention
Aerobic exercise at a dose of 300 minutes per week
Group III: 225 min/wk aerobic exerciseExperimental Treatment1 Intervention
Aerobic exercise at a dose of 225 minutes per week
Group IV: 150 min/wk aerobic exerciseExperimental Treatment1 Intervention
Aerobic exercise at a dose of 150 minutes per week
Group V: Attention controlPlacebo Group1 Intervention
Static stretching
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Aerobic exercise
2000
Completed Phase 2
~1130

Find a Location

Who is running the clinical trial?

Pennington Biomedical Research CenterLead Sponsor
309 Previous Clinical Trials
179,913 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,917 Previous Clinical Trials
41,014,246 Total Patients Enrolled
Justin C. Brown, Ph.D.Principal InvestigatorPennington Biomedical Research Center
1 Previous Clinical Trials
70 Total Patients Enrolled

Media Library

Aerobic exercise Clinical Trial Eligibility Overview. Trial Name: NCT05773144 — N/A
Colorectal Cancer Research Study Groups: Attention control, 150 min/wk aerobic exercise, 75 min/wk aerobic exercise, 300 min/wk aerobic exercise, 225 min/wk aerobic exercise
Colorectal Cancer Clinical Trial 2023: Aerobic exercise Highlights & Side Effects. Trial Name: NCT05773144 — N/A
Aerobic exercise 2023 Treatment Timeline for Medical Study. Trial Name: NCT05773144 — N/A
~135 spots leftby May 2027
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