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Combined real tDCS + IST for Hemoglobinopathy

N/A

Waitlist Available

Led By Thomas Marquardt, Ph.D.

Research Sponsored by Austin Speech Labs

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up after eight weeks of treatment

Summary

The purpose of this study is to determine if transcranial direct current stimulation (tDCS) in conjunction with intensive speech therapy will improve sentence production and word retrieval in individuals with chronic post stroke aphasia.

Eligible Conditions

Hemoglobinopathy
Aphasia
Language Disorder

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ after eight weeks of treatment

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~after eight weeks of treatment

This trial's timeline: 3 weeks for screening, Varies for treatment, and after eight weeks of treatment for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Improvement in naming Action verbs as measured by Northwestern Assessment Verbs Sentences

Improvement in naming nouns as measured by Object Naming Test

Improvement in sentence production as measured by NAVS

Secondary study objectives

Improvement in picture description as measured by Western Aphasia Battery

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: Combined real tDCS + ISTExperimental Treatment2 Interventions

Participants will receive tDCS via a Starstim device at 1mA for 20min of the total three hours of intensive speech therapy time at the beginning of each session. The stimulation will be ramped up for 45 seconds and ramped down for 15 seconds. For the experimental group, the stimulation will be ramped up for 45 seconds and stay there for 20 min. The participants will receive three weeks of tDCS and continue receiving only intensive speech therapy for five weeks for three hours a day.

Group II: Combined sham tDCS + ISTPlacebo Group2 Interventions

Participants will receive tDCS via a Starstim device at 1mA for 20min of the total three hours of intensive speech therapy time at the beginning of each session. For the sham group, the stimulation will be ramped up for 45 seconds and ramped down for 15 seconds. The stimulation will be ramped up for 45 seconds and then ramp down after the initial 45 seconds. The participants will receive three weeks of tDCS and continue receiving only intensive speech therapy for five weeks for three hours a day.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Real tDCS

2016

N/A

~210

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