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IPD Probe for Gut Permeability
N/A
Waitlist Available
Led By Guillermo Tearney, M.D, PhD.
Research Sponsored by Massachusetts General Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Subject must be 18 to 60 years of age
Be between 18 and 65 years old
Must not have
Subjects with suspected or diagnosed Galactosemia
Subjects with a history of or being on medications that delay gastric emptying
Timeline
Screening 3 weeks
Treatment Varies
Follow Up imaging data is collected during the procedure, and analyzed within 1 year of collection.
Awards & highlights
Summary
This trial is testing whether a trans-nasal IPD probe can be used to measure gut permeability.
Who is the study for?
This trial is for healthy adults aged 18-60 who can consent and fast for at least 8 hours. It's not suitable for those with respiratory diseases, nasal steroid use, gastric emptying delays, alcoholism, certain medication uses (like clotting impairments or mast cell stabilizers), recent antibiotics use, liver diseases, galactosemia, uncontrolled diabetes, lactation due to pregnancy or any contraindications to nasopharyngeal procedures.
What is being tested?
The study is testing the feasibility of a trans-nasal IPD probe as a tool to measure gut permeability. Participants will undergo this minimally invasive procedure where the probe is inserted through the nose to assess intestinal function.
What are the potential side effects?
Potential side effects may include discomfort from the nasal insertion of the probe and possible irritation in the nose or throat. There might also be risks associated with fasting and reactions specific to individual health conditions.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
I am between 18 and 60 years old.
Exclusion Criteria
You may be eligible for the trial if you check “No” for criteria below:Select...
I have been diagnosed with or suspected to have Galactosemia.
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I am on medication that slows down my stomach emptying.
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I am currently taking medication for heartburn or ulcers.
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I don't have conditions that prevent NJ tube placement like a deviated septum or sinus issues.
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I am taking medication that affects blood clotting or have a history of bleeding disorders.
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I use nasal or other steroids for my allergies.
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My diabetes is not under control.
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I am currently taking medication to stabilize mast cells.
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I have had surgery on my upper digestive tract.
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I have or might have hepatitis B or C.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ imaging data is collected during the procedure, and analyzed within 1 year of collection.
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~imaging data is collected during the procedure, and analyzed within 1 year of collection.
Treatment Details
Study Objectives
Study objectives can provide a clearer picture of what you can expect from a treatment.Primary study objectives
Baseline IPD readings
IPD readings after Glucose/Galactose infusion
Image Quality
Trial Design
1Treatment groups
Experimental Treatment
Group I: Feasibility of trans-nasal IPD probeExperimental Treatment1 Intervention
The purpose of this study is to examine the feasibility of using a trans-nasal IPD probe as a measurement tool for gut permeability
Find a Location
Who is running the clinical trial?
Massachusetts General HospitalLead Sponsor
2,993 Previous Clinical Trials
13,230,716 Total Patients Enrolled
Guillermo Tearney, M.D, PhD.Principal Investigator - Massachusetts General Hospital
Massachusetts General Hospital
6 Previous Clinical Trials
630 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- I have been diagnosed with or suspected to have Galactosemia.I am on medication that slows down my stomach emptying.I can understand and agree to the treatment plan.I am currently taking medication for heartburn or ulcers.You currently have a problem with alcohol or have had problems with alcohol in the past.I don't have conditions that prevent NJ tube placement like a deviated septum or sinus issues.I have had surgery or a disease affecting my upper respiratory system.I am taking medication that affects blood clotting or have a history of bleeding disorders.I have taken antibiotics in the last 4 weeks.I use nasal or other steroids for my allergies.I am between 18 and 60 years old.People who are in good health and do not have any medical conditions.You cannot participate if you are already enrolled in a clinical trial that involves treatments affecting how your intestines work.My diabetes is not under control.I am currently taking medication to stabilize mast cells.I have had surgery on my upper digestive tract.I had an upper respiratory infection over a week ago.I have or might have hepatitis B or C.
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Research Study Groups:
This trial has the following groups:- Group 1: Feasibility of trans-nasal IPD probe
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