Spinal anesthesia group for Dementia

N/A

Waitlist Available

Led By George Djaiani, MD

Research Sponsored by University Health Network, Toronto

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 5 years

Awards & highlights

Summary

This trialinvestigates if elderly patients are less likely to develop dementia/Alzheimers if they have spinal (awake/sedated) vs. inhalational (asleep) anesthesia for surgery, taking into account risk factors.

Eligible Conditions

Dementia
Alzheimer's Disease

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 5 years for reporting.

Treatment Details

Trial Design

2Treatment groups

Active Control

Group I: Spinal anesthesia groupActive Control4 Interventions

Spinal anesthesia group will receive bupivacaine 10-15mg anesthesia according to the standard practice. Supplemental sedation with intravenous anesthetics (midazolam/propofol) will be optional.

Group II: General anesthesia groupActive Control4 Interventions

Induction of anesthesia will be achieved with propofol 1.5-2mg/kg and fentanyl 1-3g/kg. Anesthesia will be maintained with inhalational anesthesia (isoflurane or sevoflurane) at the discretion of anesthesiologist in charge of the case. A mixture of Air/O2 will be used to maintain adequate oxygenation. Nitrous oxide will not be used.

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Who is running the clinical trial?

University Health Network, TorontoLead Sponsor

1,514 Previous Clinical Trials

499,705 Total Patients Enrolled

16 Trials studying Dementia

1,548 Patients Enrolled for Dementia

George Djaiani, MDPrincipal InvestigatorToronto General Hospital, University Health Network

4 Previous Clinical Trials

1,716 Total Patients Enrolled

~43 spots leftby Sep 2025

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