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Transcranial Magnetic Stimulation

Frequency-Varied TMS for Depression

N/A

Waitlist Available

Research Sponsored by University of California, Los Angeles

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Accompanied by at least two evidence-based augmentation therapies (Benzodiazepines do not count)

Must have confirmed diagnosis of severe Major Depressive Disorder (single or recurrent episode)

Must not have

Have an infection or poor skin condition over the scalp where the device will be positioned

Are mentally or legally incapacitated, unable to give informed consent

Timeline

Screening 3 weeks

Treatment Varies

Follow Up weekly

Awards & highlights

No Placebo-Only Group

Summary

This trial will study whether it is safe to give people transcranial magnetic stimulation (TMS) at different frequencies than the standard 10 Hz. TMS is a procedure used to treat depression. Up to 30 people will be enrolled and the trial will last 6 weeks.

Who is the study for?

This trial is for adults aged 18-65 with severe Major Depressive Disorder who haven't improved after at least four different antidepressant medications and two augmentation therapies. Participants must have tried effective psychotherapy and be able to commit to the study schedule.

What is being tested?

The trial tests repetitive Transcranial Magnetic Stimulation (TMS) at non-standard frequencies for treating depression. It involves an initial assessment, determining treatment frequency/intensity, weekly mood checks, and up to 30 TMS sessions over six weeks.

What are the potential side effects?

Potential side effects of TMS may include discomfort at the stimulation site, headache, lightheadedness, or a small risk of seizure. However, TMS is generally considered safe and well-tolerated.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am receiving two or more approved additional treatments (not including Benzodiazepines).

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I have been diagnosed with severe Major Depressive Disorder.

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My condition did not improve after trying two different types of treatment.

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I am between 18 and 65 years old.

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I have tried at least 4 different antidepressants without success.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:

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I have an infection or poor skin condition on my scalp.

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I am unable to understand or sign the consent form due to mental or legal reasons.

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I have a neurological condition like epilepsy or severe head trauma.

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I have been diagnosed with a psychotic disorder during my current depressive episode.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ weekly

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~weekly

This trial's timeline: 3 weeks for screening, Varies for treatment, and weekly for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.

Primary study objectives

Inventory of Depressive Symptoms- Self report

Awards & Highlights

No Placebo-Only Group

All patients enrolled in this study will receive some form of active treatment.

Trial Design

1Treatment groups

Experimental Treatment

Group I: SCCExperimental Treatment1 Intervention

Subjects will be treated according to their frequency response pattern which may show one or more distinct frequencies of stimulation that generated increased SCC

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Transcranial Magnetic Stimulation

2017

Completed Phase 4

~730

0 / 9Eligibility criteria met