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Behavioural Intervention

Accelerated Brain Stimulation for Depression (MediTMS Trial)

N/A
Recruiting
Led By Jyoti Mishra, PhD
Research Sponsored by University of California, San Diego
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Moderate to severe depression (PHQ-9 scale score >9 with confirmation using the Structured Clinical Interview for DSM-5 Disorders)
Be older than 18 years old
Must not have
Psychotic disorders
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 6 weeks
Awards & highlights

Summary

This trial is testing a next-generation rTMS protocol that is guided by principles of brain plasticity, in order to improve the efficacy of rTMS for the treatment of depression.

Who is the study for?
This trial is for adults with moderate to severe depression who haven't had success with 1-3 antidepressants or can't tolerate them. Participants should not have active substance abuse, psychotic disorders, metal implants in the brain, history of stroke or seizures, and shouldn't be at immediate risk of suicide.
What is being tested?
The study tests a new rTMS protocol that aims to improve brain plasticity and treat depression more effectively. It involves magnetic stimulation pulses on a specific part of the brain while patients are in a state of internal attention related to their condition.
What are the potential side effects?
rTMS may cause discomfort at the stimulation site, headache, lightheadedness, or tingling. Rarely it could lead to seizures or hearing loss if ear protection isn’t used during treatment.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have been diagnosed with moderate to severe depression.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I have a diagnosed psychotic disorder.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 6 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 6 weeks for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Change from baseline Clinical Depression (Remission)
Change from baseline brain activity in attention-to-breath task

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Medi1TMSExperimental Treatment1 Intervention
rTMS theta-burst protocol paired with a consistent attention-to-breath task
Group II: Medi2TMSActive Control1 Intervention
rTMS theta-burst protocol paired with an intermittent deep breathing task

Find a Location

Who is running the clinical trial?

University of California, San DiegoLead Sponsor
1,157 Previous Clinical Trials
1,571,369 Total Patients Enrolled
33 Trials studying Depression
59,133 Patients Enrolled for Depression
Jyoti Mishra, PhDPrincipal Investigator - University of California, San Diego
University of California, San Diego
4 Previous Clinical Trials
166 Total Patients Enrolled
2 Trials studying Depression
110 Patients Enrolled for Depression

Media Library

Meditation Accelerated Brain Stimulation (Behavioural Intervention) Clinical Trial Eligibility Overview. Trial Name: NCT04586699 — N/A
Depression Research Study Groups: Medi2TMS, Medi1TMS
Depression Clinical Trial 2023: Meditation Accelerated Brain Stimulation Highlights & Side Effects. Trial Name: NCT04586699 — N/A
Meditation Accelerated Brain Stimulation (Behavioural Intervention) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04586699 — N/A
~4 spots leftby Jan 2025
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